Journal article
Tadalafil: A Phosphodiesterase-5 Inhibitor for Benign Prostatic Hyperplasia
Pharmacotherapy, Vol.33(6), pp.639-649
06/01/2013
DOI: 10.1002/phar.1243
PMID: 23529917
Abstract
Tadalafil is a phosphodisesterase (PDE)-5 inhibitor recently approved by the United States Food and Drug Administration for lower urinary tracts symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). The mechanism for improved LUTS is thought to be related to three principal theories: alterations in nitric oxide levels, Rho-associated protein kinase deactivation, and reductions in pelvic atherosclerosis. The efficacy of PDE-5 inhibitors for the treatment of LUTS associated with BPH has been demonstrated in several randomized placebo-controlled trials. Tadalafil is thought to be superior based on an extended half-life; however, other PDE-5 inhibitors have positive results in BPH and have not been proved to be inferior to tadalafil. Before administration, concomitant use of medications such as nonselective -adrenergic antagonists, nitrates, and cytochrome P450 inhibitors should be assessed for possible drug interactions. Potential adverse drug events seen in Food and Drug Administration-approved tadalafil include back pain, dyspepsia, headache, and dizziness. Given the efficacy and safety data currently available, the PDE-5 inhibitor tadalafil represents a reasonable alternative for selected male patients with LUTS associated with BPH, especially with concomitant erectile dysfunction.
Details
- Title: Subtitle
- Tadalafil: A Phosphodiesterase-5 Inhibitor for Benign Prostatic Hyperplasia
- Creators
- Matthew A. Cantrell - University of IowaJordan Baye - University of South DakotaScott Martin Vouri - University of Health Sciences and Pharmacy
- Resource Type
- Journal article
- Publication Details
- Pharmacotherapy, Vol.33(6), pp.639-649
- Publisher
- Wiley
- DOI
- 10.1002/phar.1243
- PMID
- 23529917
- ISSN
- 0277-0008
- eISSN
- 1875-9114
- Number of pages
- 11
- Language
- English
- Date published
- 06/01/2013
- Academic Unit
- Pharmacy Practice and Science
- Record Identifier
- 9984365895302771
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