Journal article
Takotsubo Syndrome in Patients With COVID-19: A Systematic Review
CJC open (Online), Vol.6(6), pp.818-825
06/01/2024
DOI: 10.1016/j.cjco.2024.03.004
PMCID: PMC11251070
PMID: 39022174
Abstract
Background: Respiratory conditions are major physical triggers of takotsubo syndrome (TTS) and portend worse outcomes. However, data on TTS in patients with coronavirus disease -2019 infection (COVID-19) are limited. Methods: We searched PubMed, Embase, and Cochrane Library databases for case reports for the period 2019-2022 describing TTS in patients with COVID-19 pneumonia (TTS-COVID). We summarized the clinical data and outcomes and compared them to those in patients with TTS with an acute respiratory disease other than COVID-19 as a trigger (TTS-acute respiratory disease) and those with TTS with no respiratory disease (TTS-no respiratory disease). Results: The mortality rate was higher in those with TTS-COVID (26.0%) than those with TTS-acute respiratory disease (5.7%) or TTSno respiratory disease (4.2%; P < 0.001 for both). The proportion of men was higher in TTS-COVID (33.3%) than it was in TTS-no respiratory disease (9.1%; P < 0.001). The manifestations of TTS in COVID patients were atypical (dyspnea [70.3%] and cough [40.6%]); few had chest pain (23.4%). Cardiovascular risk factors were common in the TTS-COVID cohort, but fewer patients were on cardioprotective medications in this group than in the other 2 groups. Level of catecholamine use was higher in the TTS-COVID group (37.7%) than it was in the TTSno respiratory disease (10.9%; P < 0.001) group. Apical ballooning (72.6%) was the most common TTS subtype, and basal segment type was seen in 11.0% of TTS-COVID patients. Conclusions: COVID-19 patients who developed TTS had high mortality rates and unique features, compared with those in the TTS-acute respiratory disease group or the TTS-no respiratory disease group. Understanding the pathophysiology of TTS in COVID-19 may help prevent TTS and direct therapy in this setting.
Details
- Title: Subtitle
- Takotsubo Syndrome in Patients With COVID-19: A Systematic Review
- Creators
- Xiaojia Lu - First Affiliated Hospital of Shantou University Medical CollegeCatherine Teng - The University of Texas Health Science Center at San AntonioPeng Cai - Worcester Polytechnic InstituteJing Liang - Xinxiang Medical UniversityYanxuan Wang - Xinxiang Medical UniversityHawa Abu - Saint Vincent HospitalYuan Jia Wang - The University of Texas at AustinJohn E. Madias - Icahn School of Medicine at Mount SinaiKan Liu - Washington University in St. LouisQi Liu - Texas Heart InstitutePengyang Li - Virginia Commonwealth University
- Resource Type
- Journal article
- Publication Details
- CJC open (Online), Vol.6(6), pp.818-825
- Publisher
- Elsevier
- DOI
- 10.1016/j.cjco.2024.03.004
- PMID
- 39022174
- PMCID
- PMC11251070
- ISSN
- 2589-790X
- eISSN
- 2589-790X
- Number of pages
- 8
- Language
- English
- Date published
- 06/01/2024
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984657659002771
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