Journal article
Talarolutins A–D: Meroterpenoids from an endophytic fungal isolate of Talaromyces minioluteus
Phytochemistry (Oxford), Vol.126(C), pp.4-10
06/01/2016
DOI: 10.1016/j.phytochem.2016.03.013
PMCID: PMC4861051
PMID: 27048854
Abstract
[Display omitted]
•An endophytic fungus from surface-sterilized leaves of Silybum marianum (milk thistle) was investigated.•A total of five compounds was isolated from the fungal endophyte, Talaromyces minioluteus.•Among them, four were identified as meroterpenoids (named talarolutins A–D).•These meroterpenoids are of mixed biosynthetic origin, likely derived from terpene and polyketide subunits.•X-ray crystallography, NMR, and MS techniques were utilized for determining the structures of the compounds.
Four meroterpenoids [talarolutins A–D] and one known compound [purpurquinone A] were characterized from an endophytic fungal isolate of Talaromyces minioluteus (G413), which was obtained from the leaves of the medicinal plant milk thistle [Silybum marianum (L.) Gaertn. (Asteraceae)]. The structures of talarolutins A–D were determined by the analysis of various NMR and MS techniques. The relative and absolute configuration of talarolutin A was determined by X-ray diffraction analysis. A combination of NOESY data and comparisons of ECD spectra were employed to assign the relative and absolute configuration of the other analogs. Talarolutins B–D were tested for cytotoxicity against human prostate carcinoma (PC-3) cell line, antimicrobial activity, and induction of quinone reductase; no notable bioactivity was observed in any assay.
Details
- Title: Subtitle
- Talarolutins A–D: Meroterpenoids from an endophytic fungal isolate of Talaromyces minioluteus
- Creators
- Amninder Kaur - University of North Carolina at GreensboroHuzefa A. Raja - University of North Carolina at GreensboroDale C. Swenson - University of IowaRajesh Agarwal - University of MontanaGagan Deep - University of MontanaJoseph O. Falkinham - Virginia TechNicholas H. Oberlies - University of North Carolina at Greensboro
- Resource Type
- Journal article
- Publication Details
- Phytochemistry (Oxford), Vol.126(C), pp.4-10
- DOI
- 10.1016/j.phytochem.2016.03.013
- PMID
- 27048854
- PMCID
- PMC4861051
- NLM abbreviation
- Phytochemistry
- ISSN
- 0031-9422
- eISSN
- 1873-3700
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 06/01/2016
- Academic Unit
- Chemistry
- Record Identifier
- 9984622749002771
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