Journal article
Tangle analysis of difference topology experiments: applications to a Mu protein-DNA complex
Algebraic & geometric topology, Vol.9(4), pp.2247-2309
10/22/2007
DOI: 10.2140/agt.2009.9.2247
Abstract
Algebr. Geom. Topol. 9 (2009) 2247-2309 We develop topological methods for analyzing difference topology experiments involving 3-string tangles. Difference topology is a novel technique used to unveil the structure of stable protein-DNA complexes involving two or more DNA segments. We analyze such experiments for the Mu protein-DNA complex. We characterize the solutions to the corresponding tangle equations by certain knotted graphs. By investigating planarity conditions on these graphs we show that there is a unique biologically relevant solution. That is, we show there is a unique rational tangle solution, which is also the unique solution with small crossing number.
Details
- Title: Subtitle
- Tangle analysis of difference topology experiments: applications to a Mu protein-DNA complex
- Creators
- Isabel K DarcyJohn LueckeMariel Vazquez
- Resource Type
- Journal article
- Publication Details
- Algebraic & geometric topology, Vol.9(4), pp.2247-2309
- DOI
- 10.2140/agt.2009.9.2247
- ISSN
- 1472-2747
- eISSN
- 1472-2739
- Language
- English
- Date published
- 10/22/2007
- Academic Unit
- Mathematics
- Record Identifier
- 9983985838202771
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