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Tany-Seq: Integrated Analysis of the Mouse Tanycyte Transcriptome
Journal article   Open access   Peer reviewed

Tany-Seq: Integrated Analysis of the Mouse Tanycyte Transcriptome

Andrew I. Sullivan, Matthew J. Potthoff and Kyle H. Flippo
Cells (Basel, Switzerland), Vol.11(1565), p.1565
05/01/2022
DOI: 10.3390/cells11091565
PMCID: PMC9104898
PMID: 35563871
url
https://doi.org/10.3390/cells11091565View
Published (Version of record) Open Access

Abstract

The ability to maintain energy homeostasis is necessary for survival. Recently, an emerging role for ependymogial cells, which line the third ventricle in the hypothalamus in the regulation of energy homeostasis, has been appreciated. These cells are called tanycytes and are physically at the interface of brain communication with peripheral organs and have been proposed to mediate the transport of circulating hormones from the third ventricle into the parenchyma of the hypothalamus. Despite the important role tanycytes have been proposed to play in mediating communication from the periphery to the brain, we understand very little about the ontology and function of these cells due to their limited abundance and lack of ability to genetically target this cell population reliably. To overcome these hurdles, we integrated existing hypothalamic single cell RNA sequencing data, focusing on tanycytes, to allow for more in-depth characterization of tanycytic cell types and their putative functions. Overall, we expect this dataset to serve as a resource for the research community.
 hypothalamus neurogenesis ontology scRNAseq tanycyte

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