Journal article
Target telemetry in medical isotope production
Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms, Vol.10(2), pp.957-962
1985
DOI: 10.1016/0168-583X(85)90148-X
Abstract
Positron emission tomography reveals the biochemical basis underlying many disease processes. The key step is the labeling of authentic metabolic substrates, generally starting with precursor compounds of the short-lived radionuclides
11C,
13N,
15O and
18F. These, in turn, are produced on accelerators, with small cyclotrons now appearing in hospitals. The success of maintaining a reliable source of imaging agents in a clinical setting hinges more on making effective use of modest beams and energies (50 μA; 10 MeV) rather than scaling up the cyclotron in an engineering overkill. Target performance is observed by telemetry of a number of parameters during irradiation. In particular, the neutron flux can be singled out as an immediate signature of the (p, n) reaction, and serves as an important variable to optimize during the bombardment.
Details
- Title: Subtitle
- Target telemetry in medical isotope production
- Creators
- R.J. Nickles - University of Wisconsin–MadisonJ.R. Votaw - University of Wisconsin–MadisonG.D. Hutchins - University of Wisconsin–MadisonM.S. Rosenthal - University of Wisconsin–MadisonK.M. Funk - University of Wisconsin–MadisonJ.J. Sunderland - University of Wisconsin–MadisonM.R. Satter - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms, Vol.10(2), pp.957-962
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0168-583X(85)90148-X
- ISSN
- 0168-583X
- eISSN
- 1872-9584
- Language
- English
- Date published
- 1985
- Academic Unit
- Radiology; Physics and Astronomy; Radiation Oncology
- Record Identifier
- 9984313077002771
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