Journal article
Targeted Gene Silencing to Induce Permanent Sterility
Reproduction in domestic animals, Vol.47(Suppl 4), pp.228-232
08/2012
DOI: 10.1111/j.1439-0531.2012.02080.x
PMCID: PMC3516287
PMID: 22827375
Abstract
A nonsurgical method to induce sterility would be a useful tool to control feral populations of animals. Our laboratories have experience with approaches aimed at targeting brain cells\nin vivo\nwith vehicles that deliver a payload of either inhibitory RNAs or genes intended to correct cellular dysfunction. A combination/modification of these methods may provide a useful framework for the design of approaches that can be used to sterilize cats and dogs. For this approach to succeed it has to meet several conditions: It needs to target a gene essential for fertility. It must involve a method that can selectively silence the gene of interest. It also needs to deliver the silencing agent via a minimally invasive method. Finally, the silencing effect needs to be sustained for many years, so that expansion of the targeted population can be effectively prevented. In this article we discuss this subject and provide a succinct account of our previous experience with: a) molecular reagents able to disrupt reproductive cyclicity when delivered to regions of the brain involved in the control of reproduction, and b) molecular reagents able to ameliorate neuronal disease when delivered systemically using a novel approach of gene therapy.
Details
- Title: Subtitle
- Targeted Gene Silencing to Induce Permanent Sterility
- Creators
- Gregory A Dissen - Division of Neuroscience, Oregon National Primate Research Center-Oregon Health & Science University, Beaverton, OR 97006-3448, USAAlejandro Lomniczi - Division of Neuroscience, Oregon National Primate Research Center-Oregon Health & Science University, Beaverton, OR 97006-3448, USARyan L Boudreau - Department of Internal Medicine, Department of Molecular Physiology and Biophysics, Department of Neurology, University of Iowa, Iowa City, USAYong Hong Chen - Department of Internal Medicine, Department of Molecular Physiology and Biophysics, Department of Neurology, University of Iowa, Iowa City, USABeverly L Davidson - Department of Internal Medicine, Department of Molecular Physiology and Biophysics, Department of Neurology, University of Iowa, Iowa City, USASergio R Ojeda - Division of Neuroscience, Oregon National Primate Research Center-Oregon Health & Science University, Beaverton, OR 97006-3448, USA
- Resource Type
- Journal article
- Publication Details
- Reproduction in domestic animals, Vol.47(Suppl 4), pp.228-232
- DOI
- 10.1111/j.1439-0531.2012.02080.x
- PMID
- 22827375
- PMCID
- PMC3516287
- NLM abbreviation
- Reprod Domest Anim
- ISSN
- 0936-6768
- eISSN
- 1439-0531
- Grant note
- U54 HD018185 || HD / National Institute of Child Health & Human Development : NICHD\nR01 HD025123 || HD / National Institute of Child Health & Human Development : NICHD\nP51 RR000163 || RR / National Center for Research Resources : NCRR\nP51 OD011092 || OD / Office of the Director : NIH\nR01 HD024870 || HD / National Institute of Child Health & Human Development : NICHD
- Language
- English
- Date published
- 08/2012
- Academic Unit
- Iowa Neuroscience Institute; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984071637002771
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