Targeted Neonatal Echocardiography-Guided Therapy in Vein of Galen Aneurysmal Malformation: A Report of Two Cases with a Review of Physiology and Approach to Management

R. E Giesinger; Y. N Elsayed; M. P Castaldo; P. J McNamara

doi:10.1055/s-0039-1688765

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Targeted Neonatal Echocardiography-Guided Therapy in Vein of Galen Aneurysmal Malformation: A Report of Two Cases with a Review of Physiology and Approach to Management

Journal article

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Targeted Neonatal Echocardiography-Guided Therapy in Vein of Galen Aneurysmal Malformation: A Report of Two Cases with a Review of Physiology and Approach to Management

R. E Giesinger, Y. N Elsayed, M. P Castaldo and P. J McNamara

American journal of perinatology reports, Vol.9(2), pp.e172-e176

04/2019

DOI: 10.1055/s-0039-1688765

PMCID: PMC6541491

PMID: 31149387

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Abstract

Vein of Galen malformation results in predictable changes in physiology which exist on a continuum. Severe pulmonary hypertension may present as hypoxemia; however, excessive reduction in pulmonary vascular resistance may precipitate progressive pulmonary overcirculation and impaired systemic blood flow. Right ventricular performance and the patency and direction of the ductus arteriosus may play a crucial role in postductal organ perfusion. Physiological stabilization may be complex and variable over time. The utilization of targeted neonatal echocardiography to guide treatment decisions may improve the ability to provide therapy tailored to the specific disease pathophysiology and monitor serially as conditions change. An enhanced approach to physiological stabilization may reduce the risk of unexpected decompensation and allow for thoughtful, controlled endovascular embolization in appropriate candidates.

vein of Galen malformation

targeted neonatal echocardiography

hemodynamics

Case Report

Details

Title: Subtitle: Targeted Neonatal Echocardiography-Guided Therapy in Vein of Galen Aneurysmal Malformation: A Report of Two Cases with a Review of Physiology and Approach to Management
Creators: R. E Giesinger - Division of Neonatology, The Hospital for Sick Children, Toronto, Canada
Y. N Elsayed - Division of Neonatology, Health Sciences Centre, Winnipeg, Manitoba, Canada
M. P Castaldo - Division of Neonatology, The Hospital for Sick Children, Toronto, Canada
P. J McNamara - Division of Neonatology, The Hospital for Sick Children, Toronto, Canada
Resource Type: Journal article
Publication Details: American journal of perinatology reports, Vol.9(2), pp.e172-e176
DOI: 10.1055/s-0039-1688765
PMID: 31149387
PMCID: PMC6541491
NLM abbreviation: AJP Rep
ISSN: 2157-6998
eISSN: 2157-7005
Publisher: Thieme Medical Publishers
Language: English
Date published: 04/2019
Academic Unit: Stead Family Department of Pediatrics; Neonatology; Internal Medicine
Record Identifier: 9984093474302771

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