Journal article
Targeted microbiome intervention by microencapsulated delayed-release niacin beneficially affects insulin sensitivity in humans
Diabetes Care, Vol.41(3), pp.398-405
2018
DOI: 10.2337/dc17-1967
PMID: 29212824
Abstract
OBJECTIVE: Gut microbiota represent a potential novel target for future prediabetes and type 2 diabetes therapies. In that respect, niacin has been shown to beneficially affect the host-microbiome interaction in rodent models.
RESEARCH DESIGN AND METHODS: We characterized more than 500 human subjects with different metabolic phenotypes regarding their niacin (nicotinic acid [NA] and nicotinamide [NAM]) status and their gut microbiome. In addition, NA and NAM delayed-release microcapsules were engineered and examined in vitro and in vivo in two human intervention studies (bioavailability study and proof-of-concept/safety study).
RESULTS: We found a reduced α-diversity and Bacteroidetes abundance in the microbiome of obese human subjects associated with a low dietary niacin intake. We therefore developed delayed-release microcapsules targeting the ileocolonic region to deliver increasing amounts of NA and NAM to the microbiome while preventing systemic resorption to avoid negative side effects (e.g., facial flushing). In vitro studies on these delayed-release microcapsules revealed stable conditions at pH 1.4, 4.5, and 6.8, followed by release of the compounds at pH 7.4, simulating the ileocolonic region. In humans in vivo, gut-targeted delayed-release NA but not NAM produced a significant increase in the abundance of Bacteroidetes. In the absence of systemic side effects, these favorable microbiome changes induced by microencapsulated delayed-release NA were associated with an improvement of biomarkers for systemic insulin sensitivity and metabolic inflammation.
CONCLUSION: Targeted microbiome intervention by delayed-release NA might represent a future therapeutic option for prediabetes and type 2 diabetes.
Details
- Title: Subtitle
- Targeted microbiome intervention by microencapsulated delayed-release niacin beneficially affects insulin sensitivity in humans
- Creators
- Daniela FangmannKathrin TurkDominik M SchulteIsabelle RellingKatharina HartmannStefan SchreiberMatthias LaudesEva Maria TheismannJulia K KepplerJorg Rainer KnippKarin SchwarzAteequr RehmanFemke Anouska HeinsenAndre FrankePhilip RosenstielLennart LenkSandra Freitag-WolfEsther AppelStanislav GorbCharles BrennerDirk SeegertGeorg H Waetzig
- Resource Type
- Journal article
- Publication Details
- Diabetes Care, Vol.41(3), pp.398-405
- DOI
- 10.2337/dc17-1967
- PMID
- 29212824
- NLM abbreviation
- Diabetes Care
- ISSN
- 0149-5992
- eISSN
- 1935-5548
- Copyright
- © 2017 by the American Diabetes Association
- Grant note
- DOI: 10.13039/501100001659, name: German Research Foundation, award: EXC306; DOI: 10.13039/501100002347, name: Bundesministerium für Bildung und Forschung, award: FoCuS 0315540A, e:med/sysINFLAME 01ZX1306A
- Language
- English
- Date published
- 2018
- Academic Unit
- Biochemistry and Molecular Biology; Internal Medicine
- Record Identifier
- 9983788598502771
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