Journal article
Targeted polymeric nanoparticles for cancer gene therapy
Journal of drug targeting, Vol.23(7-8), pp.627-641
09/14/2015
DOI: 10.3109/1061186X.2015.1048519
PMID: 26061296
Abstract
In this article, advances in designing polymeric nanoparticles for targeted cancer gene therapy are reviewed. Characterization and evaluation of biomaterials, targeting ligands, and transcriptional elements are each discussed. Advances in biomaterials have driven improvements to nanoparticle stability and tissue targeting, conjugation of ligands to the surface of polymeric nanoparticles enable binding to specific cancer cells, and the design of transcriptional elements has enabled selective DNA expression specific to the cancer cells. Together, these features have improved the performance of polymeric nanoparticles as targeted non-viral gene delivery vectors to treat cancer. As polymeric nanoparticles can be designed to be biodegradable, non-toxic, and to have reduced immunogenicity and tumorigenicity compared to viral platforms, they have significant potential for clinical use. Results of polymeric gene therapy in clinical trials and future directions for the engineering of nanoparticle systems for targeted cancer gene therapy are also presented.
Details
- Title: Subtitle
- Targeted polymeric nanoparticles for cancer gene therapy
- Creators
- Jayoung Kim - Johns Hopkins UniversityDavid R. Wilson - Johns Hopkins UniversityCamila G. Zamboni - Johns Hopkins UniversityJordan J. Green - Johns Hopkins University
- Resource Type
- Journal article
- Publication Details
- Journal of drug targeting, Vol.23(7-8), pp.627-641
- DOI
- 10.3109/1061186X.2015.1048519
- PMID
- 26061296
- NLM abbreviation
- J Drug Target
- ISSN
- 1061-186X
- eISSN
- 1029-2330
- Publisher
- Taylor & Francis
- Number of pages
- 15
- Grant note
- R01EB016721 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) National Science Foundation; National Science Foundation (NSF) 1R01EB016721 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA T32GM007057 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) CAPES-Brazil; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) Samsung P30CA006973 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 09/14/2015
- Academic Unit
- Radiology
- Record Identifier
- 9985179682202771
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