Targeting Autophagy in Obesity‐Associated Heart Disease

Diana Castañeda; Mohanad Gabani; Soo‐Kyoung Choi; Quynh My Nguyen; Cheng Chen; Ayesha Mapara; Adam Kassan; Alexis A Gonzalez; Karima Ait-Aissa; Modar Kassan

doi:10.1002/oby.22455

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Targeting Autophagy in Obesity‐Associated Heart Disease

Journal article

Peer reviewed

Targeting Autophagy in Obesity‐Associated Heart Disease

Diana Castañeda, Mohanad Gabani, Soo‐Kyoung Choi, Quynh My Nguyen, Cheng Chen, Ayesha Mapara, Adam Kassan, Alexis A Gonzalez, Karima Ait-Aissa and Modar Kassan

Obesity (Silver Spring, Md.), Vol.27(7), pp.1050-1058

07/2019

DOI: 10.1002/oby.22455

PMID: 30938942

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Abstract

Over the past three decades, the increasing rates of obesity have led to an alarming obesity epidemic worldwide. Obesity is associated with an increased risk of cardiovascular diseases; thus, it is essential to define the molecular mechanisms by which obesity affects heart function. Individuals with obesity and overweight have shown changes in cardiac structure and function, leading to cardiomyopathy, hypertrophy, atrial fibrillation, and arrhythmia. Autophagy is a highly conserved recycling mechanism that delivers proteins and damaged organelles to lysosomes for degradation. In the hearts of patients and mouse models with obesity, this process is impaired. Furthermore, it has been shown that autophagy flux restoration in obesity models improves cardiac function. Therefore, autophagy may play an important role in mitigating the adverse effects of obesity on the heart. Throughout this review, we will discuss the benefits of autophagy on the heart in obesity and how regulating autophagy might be a therapeutic tool to reduce the risk of obesity‐associated cardiovascular diseases.

Details

Title: Subtitle: Targeting Autophagy in Obesity‐Associated Heart Disease
Creators: Diana Castañeda - California State University
Mohanad Gabani - University of Iowa Carver College of Medicine
Soo‐Kyoung Choi - Brain Korea 21 PLUS Project for Medical Science, Yonsei University
Quynh My Nguyen - University of California
Cheng Chen - Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Ayesha Mapara - Northeastern Illinois University
Adam Kassan - West Coast University
Alexis A Gonzalez - Pontificia Universidad Católica de Valparaíso
Karima Ait-Aissa - University of Iowa, Cardiovascular Medicine
Modar Kassan - University of Iowa, Internal Medicine
Resource Type: Journal article
Publication Details: Obesity (Silver Spring, Md.), Vol.27(7), pp.1050-1058
DOI: 10.1002/oby.22455
PMID: 30938942
NLM abbreviation: Obesity (Silver Spring)
ISSN: 1930-7381
eISSN: 1930-739X
Number of pages: 9
Grant note: Training, Workforce Development, and Diversity (TWD) Rise award (R25 GM061331) Basic Science Research Program of the National Research Foundation of Korea (NRF) (NRF-2018R1D1A1B07041820) American Heart Association (AHA-18CDA34030155)
Language: English
Date published: 07/2019
Academic Unit: Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984131898202771

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