Journal article
Targeting Endoplasmic Reticulum Stress as an Effective Treatment for Alcoholic Pancreatitis
Biomedicines, Vol.10(1), p.108
01/05/2022
DOI: 10.3390/biomedicines10010108
PMCID: PMC8773075
PMID: 35052788
Abstract
Pancreatitis and alcoholic pancreatitis are serious health concerns with an urgent need for effective treatment strategies. Alcohol is a known etiological factor for pancreatitis, including acute pancreatitis (AP) and chronic pancreatitis (CP). Excessive alcohol consumption induces many pathological stress responses; of particular note is endoplasmic reticulum (ER) stress and adaptive unfolded protein response (UPR). ER stress results from the accumulation of unfolded/misfolded protein in the ER and is implicated in the pathogenesis of alcoholic pancreatitis. Here, we summarize the possible mechanisms by which ER stress contributes to alcoholic pancreatitis. We also discuss potential approaches targeting ER stress and UPR in developing
therapeutic strategies for the disease.
Details
- Title: Subtitle
- Targeting Endoplasmic Reticulum Stress as an Effective Treatment for Alcoholic Pancreatitis
- Creators
- Hui Li - Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USAWen Wen - Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USAJia Luo - Iowa City VA Health Care System, Iowa City, IA 52246, USA
- Resource Type
- Journal article
- Publication Details
- Biomedicines, Vol.10(1), p.108
- DOI
- 10.3390/biomedicines10010108
- PMID
- 35052788
- PMCID
- PMC8773075
- NLM abbreviation
- Biomedicines
- ISSN
- 2227-9059
- eISSN
- 2227-9059
- Grant note
- AA015407 / NIAAA NIH HHS AA026344 / NIAAA NIH HHS AA017226 / NIAAA NIH HHS BX001721 / United States Department of Veterans Affairs
- Language
- English
- Date published
- 01/05/2022
- Academic Unit
- Pathology
- Record Identifier
- 9984211792402771
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