Targeting Wnt Signaling in Endometrial Cancer

Iram Fatima; Susmita Barman; Rajani Rai; Kristina W. Thiel; Vishal Chandra

doi:10.3390/cancers13102351

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Targeting Wnt Signaling in Endometrial Cancer

Journal article

Open access

Peer reviewed

Targeting Wnt Signaling in Endometrial Cancer

Iram Fatima, Susmita Barman, Rajani Rai, Kristina W. Thiel and Vishal Chandra

Cancers, Vol.13(10), p.2351

05/13/2021

DOI: 10.3390/cancers13102351

PMCID: PMC8152465

PMID: 34068065

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Abstract

This review presents new findings on Wnt signaling in endometrial carcinoma and implications for possible future treatments. The Wnt proteins are essential mediators in cell signaling during vertebrate embryo development. Recent biochemical and genetic studies have provided significant insight into Wnt signaling, in particular in cell cycle regulation, inflammation, and cancer. The role of Wnt signaling is well established in gastrointestinal and breast cancers, but its function in gynecologic cancers, especially in endometrial cancers, has not been well elucidated. Development of a subset of endometrial carcinomas has been attributed to activation of the APC/beta-catenin signaling pathway (due to beta-catenin mutations) and downregulation of Wnt antagonists by epigenetic silencing. The Wnt pathway also appears to be linked to estrogen and progesterone, and new findings implicate it in mTOR and Hedgehog signaling. Therapeutic interference of Wnt signaling remains a significant challenge. Herein, we discuss the Wnt-activating mechanisms in endometrial cancer and review the current advances and challenges in drug discovery.

Life Sciences & Biomedicine

Oncology

Science & Technology

Details

Title: Subtitle: Targeting Wnt Signaling in Endometrial Cancer
Creators: Iram Fatima - University of Nebraska Medical Center
Susmita Barman - University of Nebraska Medical Center
Rajani Rai - University of Oklahoma Health Sciences Center
Kristina W. Thiel - University of Iowa
Vishal Chandra - University of Oklahoma Health Sciences Center
Resource Type: Journal article
Publication Details: Cancers, Vol.13(10), p.2351
DOI: 10.3390/cancers13102351
PMID: 34068065
PMCID: PMC8152465
NLM abbreviation: Cancers (Basel)
ISSN: 2072-6694
eISSN: 2072-6694
Publisher: Mdpi
Number of pages: 23
Language: English
Date published: 05/13/2021
Academic Unit: Obstetrics and Gynecology
Record Identifier: 9984383310802771

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