Journal article
Targeting cerebral arteries for gene therapy
Experimental physiology, Vol.90(3), pp.327-331
05/2005
DOI: 10.1113/expphysiol.2004.028498
PMID: 15778412
Abstract
After the steady progress towards application of gene therapy to cerebral arterial diseases, several applications, including modification of gene expression in cerebral arteries, are now feasible. There are several possible targets for cerebrovascular gene therapy, and numerous studies have tested gene therapy strategies in animal models of cerebrovascular disorders. However, some major obstacles, especially issues of safety, must be overcome before clinical use in humans. Gene therapy for cerebral arterial diseases is still in its infancy, and many basic and preclinical studies are yet to be done in order to develop effective and safe techniques.
Details
- Title: Subtitle
- Targeting cerebral arteries for gene therapy
- Creators
- Yoshimasa Watanabe - Department of Internal Medicine, Cardiovascular Center, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USADonald D Heistad
- Resource Type
- Journal article
- Publication Details
- Experimental physiology, Vol.90(3), pp.327-331
- Publisher
- England
- DOI
- 10.1113/expphysiol.2004.028498
- PMID
- 15778412
- ISSN
- 0958-0670
- eISSN
- 1469-445X
- Grant note
- HL62984 / NHLBI NIH HHS NS24621 / NINDS NIH HHS HL16066 / NHLBI NIH HHS DK54759 / NIDDK NIH HHS
- Language
- English
- Date published
- 05/2005
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040310302771
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