Targeting device therapy: genomics of sudden death

J Michael Frangiskakis; Barry London

doi:10.1016/j.hfc.2009.08.005

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Targeting device therapy: genomics of sudden death

Journal article

Peer reviewed

Targeting device therapy: genomics of sudden death

J Michael Frangiskakis and Barry London

Heart failure clinics, Vol.6(1), pp.93-100

01/2010

DOI: 10.1016/j.hfc.2009.08.005

PMCID: PMC2833361

PMID: 19945065

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Abstract

This article discusses the development and use of genomic predictors to define the population at risk for sudden cardiac death, which is usually defined as death from cardiac causes within an hour of symptom onset. The identification of genetic predictors of sudden death in heart failure is in its earliest stages. Mutations in ion channels have been shown to cause inherited forms of sudden death; there is, however, little evidence that mutations or rare single nucleotide polymorphisms (SNPs) in those genes are important causes of the common forms of sudden death. Other common variants in ion channels and related genes are associated with sudden death in the setting of acute myocardial infarction or heart failure. Ultimately, we hope to identify a handful of SNPs that modulate the risk of sudden death in heart failure and to develop an algorithm to predict risk based on genotype.

Heart Failure - complications

Risk Assessment

Genomics

Humans

Ion Channels - genetics

Death, Sudden, Cardiac - prevention & control

Heart Failure - genetics

Death, Sudden, Cardiac - etiology

Polymorphism, Genetic

Genetic Variation

Heart Failure - therapy

Animals

Defibrillators, Implantable

Arrhythmias, Cardiac - complications

Polymorphism, Single Nucleotide

Arrhythmias, Cardiac - genetics

Details

Title: Subtitle: Targeting device therapy: genomics of sudden death
Creators: J Michael Frangiskakis - Division of Cardiology, Cardiovascular Institute, University of Pittsburgh Medical Center, Scaife S-572, 200 Lothrop Street, Pittsburgh, PA 15213-2582, USA
Barry London
Resource Type: Journal article
Publication Details: Heart failure clinics, Vol.6(1), pp.93-100
DOI: 10.1016/j.hfc.2009.08.005
PMID: 19945065
PMCID: PMC2833361
NLM abbreviation: Heart Fail Clin
ISSN: 1551-7136
eISSN: 2374-9334
Publisher: United States
Grant note: R01 HL077398-05 / NHLBI NIH HHS R01 HL077398-01 / NHLBI NIH HHS R01 HL062300-07A1 / NHLBI NIH HHS R01 HL062300-08 / NHLBI NIH HHS R01 HL062300-04A1 / NHLBI NIH HHS R01 HL062300-03 / NHLBI NIH HHS R01 HL077398-04 / NHLBI NIH HHS R01 HL077398 / NHLBI NIH HHS R01 HL077398-03 / NHLBI NIH HHS R01 HL062300-01 / NHLBI NIH HHS R01 HL062300-05 / NHLBI NIH HHS R01 HL062300-09 / NHLBI NIH HHS R01 HL062300-06 / NHLBI NIH HHS R01 HL062300 / NHLBI NIH HHS R01 HL077398-02 / NHLBI NIH HHS DP1 OD003819 / NIH HHS R01 HL062300-02 / NHLBI NIH HHS
Language: English
Date published: 01/2010
Academic Unit: Molecular Physiology and Biophysics; Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984025700202771

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