Journal article
Targeting molecular signals in chk1 pathways as a new approach for overcoming drug resistance
Cancer and metastasis reviews, Vol.20(1/2), pp.109-115
01/01/2001
DOI: 10.1023/A:1013116826788
PMID: 11831638
Abstract
The common clinical problem in the successful treatment of cancer is the resistance of cancer cells to chemotherapeutic drugs. Chemotherapy kills drug-sensitive cells, but leaves behind a higher proportion of drug-resistant cells. The resistance can be due to altered drug accumulation, retention, metabolism and distribution, or to reduced drug-target interaction. More recently, cell cycle progression, DNA mismatch repair (MMR) and cell death have been shown to play an important role in the regulation of cell resistance to anticancer drugs. Chkl regulation pathways, DNA MMR and p73, as well as altered apoptotic cell death involved in the cell resistance toward DNA damaging agents will be reviewed in this article.
Details
- Title: Subtitle
- Targeting molecular signals in chk1 pathways as a new approach for overcoming drug resistance
- Creators
- Gunnar Hapke - Roswell Park Cancer InstituteYin Ming-biaoYoucef Rustum - Roswell Park Cancer Institute
- Resource Type
- Journal article
- Publication Details
- Cancer and metastasis reviews, Vol.20(1/2), pp.109-115
- Publisher
- Springer Nature B.V
- DOI
- 10.1023/A:1013116826788
- PMID
- 11831638
- ISSN
- 0167-7659
- eISSN
- 1573-7233
- Language
- English
- Date published
- 01/01/2001
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359775402771
Metrics
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