Targeting protein prenylation in progeria

Stephen G Young; Shao H Yang; Brandon S J Davies; Hea-Jin Jung; Loren G Fong

doi:10.1126/scitranslmed.3005229

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Targeting protein prenylation in progeria

Journal article

Peer reviewed

Targeting protein prenylation in progeria

Stephen G Young, Shao H Yang, Brandon S J Davies, Hea-Jin Jung and Loren G Fong

Science translational medicine, Vol.5(171), pp.171ps3-171ps3

02/06/2013

DOI: 10.1126/scitranslmed.3005229

PMCID: PMC3725554

PMID: 23390246

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https://www.ncbi.nlm.nih.gov/pmc/articles/3725554View

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Abstract

A clinical trial of a protein farnesyltransferase inhibitor (lonafarnib) for the treatment of Hutchinson-Gilford progeria syndrome (HGPS) was recently completed. Here, we discuss the mutation that causes HGPS, the rationale for inhibiting protein farnesyltransferase, the potential limitations of this therapeutic approach, and new potential strategies for treating the disease.

Protein Prenylation - drug effects

Humans

Progeria - enzymology

Enzyme Inhibitors - pharmacology

Cell Nucleus Shape - drug effects

Clinical Trials as Topic

Progeria - genetics

Enzyme Inhibitors - therapeutic use

Progeria - drug therapy

Farnesyltranstransferase - metabolism

Animals

Progeria - pathology

Lamins - metabolism

Farnesyltranstransferase - antagonists & inhibitors

Details

Title: Subtitle: Targeting protein prenylation in progeria
Creators: Stephen G Young - Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. sgyoung@mednet
Shao H Yang
Brandon S J Davies
Hea-Jin Jung
Loren G Fong
Resource Type: Journal article
Publication Details: Science translational medicine, Vol.5(171), pp.171ps3-171ps3
DOI: 10.1126/scitranslmed.3005229
PMID: 23390246
PMCID: PMC3725554
NLM abbreviation: Sci Transl Med
ISSN: 1946-6234
eISSN: 1946-6242
Publisher: United States
Grant note: AG035626 / NIA NIH HHS HL089781 / NHLBI NIH HHS R01 HL089781 / NHLBI NIH HHS R01 AG035626 / NIA NIH HHS R01 HL086683 / NHLBI NIH HHS HL086683 / NHLBI NIH HHS
Language: English
Date published: 02/06/2013
Academic Unit: Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology
Record Identifier: 9984024542902771

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