Journal article
Targeting reperfusion injury in acute myocardial infarction: a review of reperfusion injury pharmacotherapy
Expert opinion on pharmacotherapy, Vol.13(8), pp.1153-1175
06/01/2012
DOI: 10.1517/14656566.2012.685163
PMID: 22594845
Abstract
Introduction:
Acute myocardial infarction (AMI) (secondary to lethal ischemia-reperfusion [IR]) contributes to much of the mortality and morbidity from ischemic heart disease. Currently, the treatment for AMI is early reperfusion; however, this itself contributes to the final myocardial infarct size, in the form of what has been termed 'lethal reperfusion injury'. Over the last few decades, the discovery of the phenomena of ischemic preconditioning and postconditioning, as well as remote preconditioning and remote postconditioning, along with significant advances in our understanding of the cardioprotective pathways underlying these phenomena, have provided the possibility of successful mechanical and pharmacological interventions against reperfusion injury.
Areas covered:
This review summarizes the evidence from clinical trials evaluating pharmacological agents as adjuncts to standard reperfusion therapy for ST-elevation AMI.
Expert opinion:
Reperfusion injury pharmacotherapy has moved from bench to bedside, with clinical evaluation and ongoing clinical trials providing us with valuable insights into the shortcomings of current research in establishing successful treatments for reducing reperfusion injury. There is a need to address some key issues that may be leading to lack of translation of cardioprotection seen in basic models to the clinical setting. These issues are discussed in the Expert opinion section.
Details
- Title: Subtitle
- Targeting reperfusion injury in acute myocardial infarction: a review of reperfusion injury pharmacotherapy
- Creators
- Vikram Sharma - The Hatter Cardiovascular InstituteRobert M Bell - The Hatter Cardiovascular InstituteDerek M Yellon - The Hatter Cardiovascular Institute
- Resource Type
- Journal article
- Publication Details
- Expert opinion on pharmacotherapy, Vol.13(8), pp.1153-1175
- Publisher
- Informa UK, Ltd
- DOI
- 10.1517/14656566.2012.685163
- PMID
- 22594845
- ISSN
- 1465-6566
- eISSN
- 1744-7666
- Number of pages
- 23
- Language
- English
- Date published
- 06/01/2012
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806609802771
Metrics
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