Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease

Nitin J Karandikar; Carol L Vanderlugt; Jeffrey A Bluestone; Stephen D Miller

doi:10.1016/S0165-5728(98)00058-7

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Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease

Journal article

Peer reviewed

Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease

Nitin J Karandikar, Carol L Vanderlugt, Jeffrey A Bluestone and Stephen D Miller

Journal of neuroimmunology, Vol.89(1), pp.10-18

1998

DOI: 10.1016/S0165-5728(98)00058-7

PMID: 9726820

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Abstract

The B7/CD28:CTLA-4 costimulatory pathway plays a critical role in determining the fate of immmune responses (activation vs. down-regulation) and is a highly promising therapeutic target for treating autoimmune diseases. In this review, we highlight the mechanisms by which this costimulatory pathway operates emphasizing the role of the different components in the pathogenesis of relapsing experimental autoimmmune encephalomyelitis, a CD4 T cell-mediated autoimmune model of multiple sclerosis. The separate and distinct roles of B7-1, B7-2 and CTLA-4 in positive and negative regulation of autoimmune pathogenesis are considered and a working model is proposed.

Central nervous system (CNS)

Experimental autoimmune encephalomyelitis (EAE)

B7/CD28:CTLA-4 costimulatory system

Details

Title: Subtitle: Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease
Creators: Nitin J Karandikar - Department of Microbiology-Immunology and Interdepartmental Immunobiology Center, North western University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
Carol L Vanderlugt - Department of Microbiology-Immunology and Interdepartmental Immunobiology Center, North western University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
Jeffrey A Bluestone - The Ben May Institute for Cancer Research and the Committee of Immunology, The University of Chicago, Chicago, IL 60637, USA
Stephen D Miller - Department of Microbiology-Immunology and Interdepartmental Immunobiology Center, North western University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
Resource Type: Journal article
Publication Details: Journal of neuroimmunology, Vol.89(1), pp.10-18
Publisher: Elsevier B.V
DOI: 10.1016/S0165-5728(98)00058-7
PMID: 9726820
ISSN: 0165-5728
eISSN: 1872-8421
Language: English
Date published: 1998
Academic Unit: Pathology
Record Identifier: 9984047993002771

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