Journal article
Task-specific contribution of the human striatum to perceptual-motor skill learning
Journal of clinical and experimental neuropsychology, Vol.33(1), pp.51-62
01/05/2011
DOI: 10.1080/13803395.2010.493144
PMID: 20603739
Abstract
Acquisition of new perceptual-motor skills depends on multiple brain areas, including the striatum. However, the specific contribution of each structure to this type of learning is still poorly understood. Focusing on the striatum, we proposed (a) to replicate the finding of impaired rotary pursuit (RP) and preserved mirror tracing (MT) in Huntington's disease (HD); and (b) to further explore this putative learning dissociation with other human models of striatal dysfunction (i.e., Parkinson's disease and focal vascular damage) and two new paradigms (i.e., Geometric Figures, GF, and Control Stick, CS) of skill learning. Regardless of the etiology, participants with damage to the striatum showed impaired learning of visuomotor tracking skills (i.e., RP and GF), whereas the ability to learn skills that require motor adaptation (i.e., MT and CS) was not affected. These results suggest a task-specific involvement of the striatum in the early stages of skill learning.
Details
- Title: Subtitle
- Task-specific contribution of the human striatum to perceptual-motor skill learning
- Creators
- Sara Cavaco - Laboratory of Neurobiology of Human Behavior, Centro Hospitalar do PortoSteven W Anderson - Division of Behavioral Neurology and Cognitive Neuroscience , University of IowaMarina Magalhães - Department of Neurology , Centro Hospitalar do PortoManuel Correia - Department of Neurology , Centro Hospitalar do PortoCláudia Pereira - Department of Neuroradiology , Centro Hospitalar do PortoAssunção Tuna - Department of Neurology , Centro Hospitalar do PortoRicardo Taipa - Department of Neurology , Centro Hospitalar do PortoPedro Pinto - Department of Neuroradiology , Centro Hospitalar do PortoCláudia Pinto - Laboratory of Neurobiology of Human Behavior, Centro Hospitalar do PortoRomeu Cruz - Department of Neuroradiology , Centro Hospitalar do PortoAntónio Bastos Lima - UMIB, Instituto Ciências Biomédicas Abel SalazarAlexandre Castro-Caldas - Universidade Católica PortuguesaAntónio Martins da Silva - Department of Neurophysiology , Centro Hospitalar do PortoHanna Damásio - Dornsife Cognitive Neuroscience Imaging Center, University of Southern California
- Resource Type
- Journal article
- Publication Details
- Journal of clinical and experimental neuropsychology, Vol.33(1), pp.51-62
- DOI
- 10.1080/13803395.2010.493144
- PMID
- 20603739
- NLM abbreviation
- J Clin Exp Neuropsychol
- ISSN
- 1380-3395
- eISSN
- 1744-411X
- Publisher
- Taylor & Francis Group
- Language
- English
- Date published
- 01/05/2011
- Academic Unit
- Neurology
- Record Identifier
- 9984020742302771
Metrics
23 Record Views