Journal article
Tau and src family tyrosine kinases
Biochimica et biophysica acta. Molecular basis of disease, Vol.1739(2), pp.323-330
2005
DOI: 10.1016/j.bbadis.2004.09.002
PMID: 15615649
Abstract
The interaction between tau and src family non-receptor tyrosine kinases represents a new function for tau. Mediated by the proline-rich region of tau and the SH3 domain of fyn or src, this interaction has the potential to confer novel cellular activities for tau in the growth cone and in the membrane. The subsequent finding that tau is tyrosine phosphorylated has led to the observation that tau in neurofibrillary tangles is tyrosine phosphorylated. Therefore, a role for tyrosine kinases such as fyn in neuropathogenesis is predicted.
Details
- Title: Subtitle
- Tau and src family tyrosine kinases
- Creators
- Gloria Lee - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- Biochimica et biophysica acta. Molecular basis of disease, Vol.1739(2), pp.323-330
- DOI
- 10.1016/j.bbadis.2004.09.002
- PMID
- 15615649
- NLM abbreviation
- Biochim Biophys Acta Mol Basis Dis
- ISSN
- 0925-4439
- eISSN
- 1879-260X
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 2005
- Academic Unit
- Iowa Neuroscience Institute; Immunology; Internal Medicine
- Record Identifier
- 9984065489402771
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