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Tau and tauopathies
Journal article   Open access   Peer reviewed

Tau and tauopathies

Gloria Lee and Chad J Leugers
Progress in molecular biology and translational science, Vol.107, pp.263-293
2012
DOI: 10.1016/B978-0-12-385883-2.00004-7
PMCID: PMC3614411
PMID: 22482453
url
https://www.ncbi.nlm.nih.gov/pmc/articles/3614411View
Open Access

Abstract

Tauopathies are age-related neurodegenerative diseases that are characterized by the presence of aggregates of abnormally phosphorylated tau. As tau was originally discovered as a microtubule-associated protein, it has been hypothesized that neurodegeneration results from a loss of the ability of tau to associate with microtubules. However, tau has been found to have other functions aside from the promotion and stabilization of microtubule assembly. It is conceivable that such functions may be affected by the abnormal phosphorylation of tau and might have consequences for neuronal function or viability. This chapter provides an overview of tau structure, functions, and its involvement in neurodegenerative diseases.
 Phosphorylation Tauopathies - genetics Humans Translational Medical Research tau Proteins - metabolism tau Proteins - chemistry Tauopathies - etiology Tauopathies - metabolism Animals Protein Isoforms - metabolism tau Proteins - genetics Protein Isoforms - chemistry Cytoskeleton - metabolism Mice Protein Interaction Domains and Motifs Models, Neurological Mutation Protein Isoforms - genetics

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