Journal article
Technical issues in the determination of cerebrovascular reserve in elderly subjects using 15O-water PET imaging
NeuroImage (Orlando, Fla.), Vol.21(1), pp.201-210
2004
DOI: 10.1016/j.neuroimage.2003.09.044
PMID: 14741657
Abstract
The accurate determination of cerebrovascular reserve (CVR), especially in elderly subjects, entails several technical issues. From a review of the literature, the optimal technique employs quantitative
15O-water PET imaging determinations of cerebral blood flow (CBF) and acetazolamide (ACZ) (1 g iv with measurements at 10- to 20-min post-administration) as the vasodilating agent. CBF and CVR measurements were made using this methodology on 12 elderly subjects (3 males, 9 females, 66–84 years of age) meeting criteria for mild cognitive impairment (MCI) without other significant medical problems. Applying this quantitative technique, the cognitive and emotional status of the subject during the imaging procedure influenced the magnitude of the measurements. The semiquantitative measures resulted in even more pronounced subject state influences. The conditions under which CBF or CVR measurements are made should be controlled and reported. If semiquantitative techniques (e.g., single-photon emission-computed tomography [SPECT] imaging) must be employed for the determination of CVR, the validity of any measurement is dependent on the careful control of the general physiological status (e.g., heart rate, blood pressure, level of anxiety) of the patient.
Details
- Title: Subtitle
- Technical issues in the determination of cerebrovascular reserve in elderly subjects using 15O-water PET imaging
- Creators
- Laura L Boles Ponto - Positron Emission Tomography Imaging Center, Department of Radiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USASusan K Schultz - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USAG. Leonard Watkins - Positron Emission Tomography Imaging Center, Department of Radiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USARichard D Hichwa - Positron Emission Tomography Imaging Center, Department of Radiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- NeuroImage (Orlando, Fla.), Vol.21(1), pp.201-210
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.neuroimage.2003.09.044
- PMID
- 14741657
- ISSN
- 1053-8119
- eISSN
- 1095-9572
- Language
- English
- Date published
- 2004
- Academic Unit
- Radiology; Psychiatry; Research Administration; Pharmaceutical Sciences and Experimental Therapeutics; Physics and Astronomy; Radiation Oncology
- Record Identifier
- 9984051988002771
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