Journal article
Technical report: gadoxetate-disodium-enhanced 2D R2mapping: a novel approach for assessing bile ducts in living donors
Abdominal radiology (New York), Vol.43(7), pp.1656-1660
07/01/2018
DOI: 10.1007/s00261-017-1365-3
PMCID: PMC6042650
PMID: 29086007
Abstract
Gadoxetate-disodium (Gd-EOB-DTPA)-enhanced 3D T1- weighted (T1w) MR cholangiography (MRC) is an efficient method to evaluate biliary anatomy due to T1 shortening of excreted contrast in the bile. A method that exploits both T1 shortening and T2* effects may produce even greater bile duct conspicuity. The aim of our study is to determine feasibility and compare the diagnostic performance of two-dimensional (2D) T1w multi-echo (ME) spoiled gradient-recalled-echo (SPGR) derived R2* maps against T1w MRC for bile duct visualization in living liver donor candidates.
Ten potential living liver donor candidates underwent pretransplant 3T MRI and were included in our study. Following injection of Gd-EOBDTPA and a 20-min delay, 3D T1w MRC and 2D T1w ME SPGR images were acquired. 2D R2* maps were generated inline by the scanner assuming exponential decay. The 3D T1w MRC and 2D R2* maps were retrospectively and independently reviewed in two separate sessions by three radiologists. Visualization of eight bile duct segments was scored using a 4-point ordinal scale. The scores were compared using mixed effects regression model.
Imaging was tolerated by all donors and R2* maps were successfully generated in all cases. Visualization scores of 2D R2* maps were significantly higher than 3D T1w MRC for right anterior (p = 0.003) and posterior (p = 0.0001), segment 2 (p < 0.0001), segment 3 (p = 0.0001), and segment 4 (p < 0.0001) ducts.
Gd-EOB-DTPA-enhanced 2D R2* mapping is a feasible method for evaluating the bile ducts in living donors and may be a valuable addition to the living liver donor MR protocol for delineating intrahepatic biliary anatomy.
Details
- Title: Subtitle
- Technical report: gadoxetate-disodium-enhanced 2D R2mapping: a novel approach for assessing bile ducts in living donors
- Creators
- Soudabeh Fazeli Dehkordy - University of California—San DiegoKathryn J. Fowler - Washington University,Tanya Wolfson - San Diego Supercomputer CenterSaya Igarashi - University of California—San DiegoCarolina P. Lamas Constantino - University of California, San DiegoJonathan C. Hooker - University of California—San DiegoCheng W. Hong - University of California—San DiegoAdrija Mamidipalli - University of California—San DiegoAnthony C. Gamst - San Diego Supercomputer CenterAlan Hemming - University of California—San DiegoClaude B. Sirlin - University of California—San Diego
- Resource Type
- Journal article
- Publication Details
- Abdominal radiology (New York), Vol.43(7), pp.1656-1660
- Publisher
- Springer Nature
- DOI
- 10.1007/s00261-017-1365-3
- PMID
- 29086007
- PMCID
- PMC6042650
- ISSN
- 2366-004X
- eISSN
- 2366-0058
- Number of pages
- 5
- Grant note
- R01DK075128 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) T32 EB005970-09 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA T32EB005970 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB)
- Language
- English
- Date published
- 07/01/2018
- Academic Unit
- Surgery
- Record Identifier
- 9984322816902771
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