Techniques, Models, and Variables of Interest in Studies of Intrinsic Laryngeal Muscle Fiber Types: A Bibliometric Analysis

Christopher S Apfelbach; Lady Catherine Cantor-Cutiva; Adrián Castillo-Allendes; Eric J Hunter

doi:10.1016/j.jvoice.2024.12.018

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Techniques, Models, and Variables of Interest in Studies of Intrinsic Laryngeal Muscle Fiber Types: A Bibliometric Analysis

Journal article

Peer reviewed

Techniques, Models, and Variables of Interest in Studies of Intrinsic Laryngeal Muscle Fiber Types: A Bibliometric Analysis

Christopher S Apfelbach, Lady Catherine Cantor-Cutiva, Adrián Castillo-Allendes and Eric J Hunter

Journal of voice

01/04/2025

DOI: 10.1016/j.jvoice.2024.12.018

PMID: 39757084

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Abstract

Introduction Laryngeal muscle physiology is integral to many speech, voice, swallowing, and respiratory functions. A key determinant of a muscle’s contractile properties, including its fatigue profile and capacity for force production, is the myosin heavy chain (MyHC) isoform that predominates in the muscle. This study surveys literature on the MyHC compositions of mammalian intrinsic laryngeal skeletal muscle to illustrate trends and gaps in laryngeal muscle fiber typing techniques, models, and concepts. Methods The Embase, Scopus, Medline, Web of Science, and Cochrane databases were systematically searched for studies of mammalian intrinsic laryngeal muscle MyHC composition. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for systematic reviews, 1531 non-duplicate papers were identified; 146 were selected for full-text screening. One hundred twenty papers were included in the final bibliometric analysis, which aimed to highlight key concepts in the literature. Results Publication of intrinsic laryngeal MyHC studies peaked in the early 2000s and has since declined. Although early research predominantly used histochemical techniques and large mammalian models (cow, sheep, dog, horse, etc), practice has evolved to focus on electrophoretic, immunohistochemical, and transcriptomic fiber typing techniques in rats and humans. Comparatively few studies have examined how experimental manipulations affect laryngeal muscle MyHC composition. Discussion Three areas of laryngeal muscle physiology lack a large body of supporting literature: (1) MyHC responses to stimuli such as training and disease, (2) MyHC plasticity across the lifespan, and (3) MyHC heterogeneity within muscle fibers (MyHC polymorphisms) and across muscle fibers (topographical MyHC distribution). We propose new avenues for research, education, and discussion in these three subdomains.

Laryngeal muscle—Fiber type—Myosin heavy chains—Vocal fatigue—Muscle plasticity—Bibliometric analysis

Details

Title: Subtitle: Techniques, Models, and Variables of Interest in Studies of Intrinsic Laryngeal Muscle Fiber Types: A Bibliometric Analysis
Creators: Christopher S Apfelbach (Corresponding Author) - University of Minnesota
Lady Catherine Cantor-Cutiva (Author) - University of Iowa
Adrián Castillo-Allendes (Author) - Michigan State University
Eric J Hunter (Author) - University of Iowa
Resource Type: Journal article
Publication Details: Journal of voice
DOI: 10.1016/j.jvoice.2024.12.018
PMID: 39757084
NLM abbreviation: J Voice
ISSN: 0892-1997
eISSN: 1873-4588
Publisher: Elsevier Inc
Language: English
Electronic publication date: 01/04/2025
Academic Unit: Communication Sciences and Disorders; Teaching and Learning; Otolaryngology
Record Identifier: 9985089631902771

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