Journal article
Telaprevir-based triple therapy for hepatitis C null responders among living donor liver transplant recipients
Bioscience trends, Vol.8(6), pp.339-345
12/01/2014
DOI: 10.5582/bst.2014.01101
PMID: 25641181
Abstract
Telaprevir (TVR), a direct -acting protease inhibitor, was recently reported to improve treatment efficacy when used in combination with peg-interferon (PEG-IFN) and ribavirin (RBV) as triple therapy for HCV in non-transplant patients. The aim of the present study was to investigate the feasibility of TVR-based triple therapy among Japanese living donor liver transplant (LDLT) recipients who had been resistant to dual treatment with PEG-IFN and RBV. Among 133 HCV-positive LDLT recipients, 8 null responders during or after dual treatment with PEG-IFN and RBV were finally indicated for TVR-based triple therapy after treatment. All 8 patients had been resistant to dual treatment with PEG-IFN and RBV. While the cyclosporine trough level was well controlled with an 80% dose reduction during TVR administration, the end - of - treatment response rate was only 25% (2/8), with 63% (5/8) of patients developing anemia that required a blood transfusion and 50% (4/8) of patients developing leukopenia that required filgrastim. Dose reduction or treatment discontinuation was required in all cases. Based on the poor efficacy and the unacceptable high rate of cytopenic events, TVR-based triple therapy is not indicated for those resistant to dual treatment with PEG-IFN and RBV.
Details
- Title: Subtitle
- Telaprevir-based triple therapy for hepatitis C null responders among living donor liver transplant recipients
- Creators
- Junichi Kaneko - The University of TokyoYasuhiko Sugawara - The University of TokyoTakamune Yamaguchi - The University of TokyoNobuhiro Harada - The University of TokyoNobuhisa Akamatsu - The University of TokyoTakeaki Ishizawa - The University of TokyoTaku Aoki - The University of TokyoYoshihiro Sakamoto - The University of TokyoKiyoshi Hasegawa - The University of TokyoSumihito Tamura - The University of TokyoTomohiro Tanaka - The University of TokyoNorihiro Kokudo - The University of Tokyo
- Resource Type
- Journal article
- Publication Details
- Bioscience trends, Vol.8(6), pp.339-345
- Publisher
- Irca-Bssa
- DOI
- 10.5582/bst.2014.01101
- PMID
- 25641181
- ISSN
- 1881-7815
- eISSN
- 1881-7823
- Number of pages
- 7
- Language
- English
- Date published
- 12/01/2014
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984359820502771
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