Journal article
Telotristat ethyl: a novel agent for the therapy of carcinoid syndrome diarrhea
Future oncology (London, England), Vol.14(12), pp.1155-1164
05/01/2018
DOI: 10.2217/fon-2017-0340
PMCID: PMC6734517
PMID: 29350062
Abstract
Carcinoid syndrome (CS), characterized by diarrhea and flushing, is present in 20% of patients with neuroendocrine tumors at diagnosis and becomes more frequent with progression. The diarrhea of CS is caused mainly by tumoral secretion of serotonin. It may not be fully controlled by somatostatin analogs, the currently indicated drugs for symptomatic relief. Telotristat ethyl is a novel inhibitor of tryptophan hydroxylase, the rate-limiting enzyme in serotonin biosynthesis. Administration of the drug decreases diarrhea in patients with CS. Telotristat ethyl was approved in February 2017 (USA) and September 2017 (European Commission) for the treatment of CS diarrhea in adults inadequately controlled by somatostatin analog alone. This drug is expected to greatly improve the health and quality of life of patients with CS diarrhea.
Details
- Title: Subtitle
- Telotristat ethyl: a novel agent for the therapy of carcinoid syndrome diarrhea
- Creators
- Joseph S. Dillon - Division of Endocrinology, University of Iowa Hospital & VA Medical Center, Iowa City, IA 52242, USAChandrikha Chandrasekharan - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Future oncology (London, England), Vol.14(12), pp.1155-1164
- Publisher
- Future Medicine Ltd
- DOI
- 10.2217/fon-2017-0340
- PMID
- 29350062
- PMCID
- PMC6734517
- ISSN
- 1479-6694
- eISSN
- 1744-8301
- Number of pages
- 10
- Grant note
- NIH P50 CA174521 / NIH SPORE grant in Neuroendocrine Tumors Lexicon Pharmaceuticals, Inc, The Woodlands, TX P50CA174521 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 05/01/2018
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984360060002771
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