Temperature-induced reciprocal activation of hippocampal field activity

Karl A E Karlsson; Mark S Blumberg

doi:10.1152/jn.00953.2003

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Temperature-induced reciprocal activation of hippocampal field activity

Journal article

Peer reviewed

Temperature-induced reciprocal activation of hippocampal field activity

Karl A E Karlsson and Mark S Blumberg

Journal of neurophysiology, Vol.91(1), pp.583-588

01/2004

DOI: 10.1152/jn.00953.2003

PMID: 14573549

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Abstract

Hippocampal network activity oscillates between sustained rhythms (e.g., theta) and aperiodic population spikes (e.g., sharp waves, dentate spikes). Although temperature is known to modulate various aspects of rhythmic hippocampal activity, little is known regarding the influence of temperature on the incidence of population spikes. We recorded spontaneous hippocampal activity along the CA1-dentate gyrus axis using multisite silicon electrodes in urethanized infant rats (P2-P16) at brain temperatures of 37 and 27 degrees C. Theta and gamma activity, as well as sharp waves, were detected at 37 degrees C but not at 27 degrees C. In contrast, dentate spikes were rare at 37 degrees C but their incidence increased several-fold at 27 degrees C (epileptiform activity also emerged at 27 degrees C in the oldest pups). This surprising increase in the incidence of dentate spike activity in a cold brain represents the first such demonstration for a neuronal field pattern. In addition, these findings indicate that changes in brain temperature produce systems-level shifts in the balance among reciprocally interacting hippocampal components.

Animals, Newborn

Cold Temperature

Temperature

Electric Stimulation

Age Factors

Rats

Evoked Potentials - physiology

Male

Hot Temperature

Hippocampus - cytology

Rats, Sprague-Dawley

Cortical Synchronization

Animals

Electrophysiology - methods

Analysis of Variance

Hippocampus - physiology

Theta Rhythm

Details

Title: Subtitle: Temperature-induced reciprocal activation of hippocampal field activity
Creators: Karl A E Karlsson - Program in Behavioral and Cognitive Neuroscience, Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USA
Mark S Blumberg
Resource Type: Journal article
Publication Details: Journal of neurophysiology, Vol.91(1), pp.583-588
DOI: 10.1152/jn.00953.2003
PMID: 14573549
NLM abbreviation: J Neurophysiol
ISSN: 0022-3077
eISSN: 1522-1598
Publisher: United States
Grant note: MH-50701 / NIMH NIH HHS HD-38708 / NICHD NIH HHS MH-66424 / NIMH NIH HHS P41-RR-09754 / NCRR NIH HHS
Language: English
Date published: 01/2004
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute; Biology
Record Identifier: 9984002475402771

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