Temporal Learning Among Prefrontal and Striatal Ensembles

Eric Emmons; Gabriela Tunes-Chiuffa; Jeeyu Choi; R Austin Bruce; Matthew A Weber; Youngcho Kim; Nandakumar S Narayanan

doi:10.1093/texcom/tgaa058

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Temporal Learning Among Prefrontal and Striatal Ensembles

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Temporal Learning Among Prefrontal and Striatal Ensembles

Eric Emmons, Gabriela Tunes-Chiuffa, Jeeyu Choi, R Austin Bruce, Matthew A Weber, Youngcho Kim and Nandakumar S Narayanan

Cerebral Cortex Communications, Vol.1(1), tgaa058

08/05/2020

DOI: 10.1093/texcom/tgaa058

PMCID: PMC8152894

PMID: 34296121

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Abstract

AbstractBehavioral flexibility requires the prefrontal cortex and striatum, but it is unclear if these structures play similar or distinct roles in adapting to novel circumstances. Here, we investigate neuronal ensembles in the medial frontal cortex (MFC) and the dorsomedial striatum (DMS) during one form of behavioral flexibility: learning a new temporal interval. We studied corticostriatal neuronal activity as rodents trained to respond after a 12-s fixed interval (FI12) learned to respond at a shorter 3-s fixed interval (FI3). On FI12 trials, we found that a key form of temporal processing—time-related ramping activity—decreased in the MFC but did not change in the DMS as animals learned to respond at a shorter interval. However, while MFC and DMS ramping was stable with successive days of two-interval performance, temporal decoding by DMS ensembles improved on FI3 trials. Finally, when comparing FI12 versus FI3 trials, we found that more DMS neurons than MFC neurons exhibited differential interval-related activity early in two-interval performance. These data suggest that the MFC and DMS play distinct roles during temporal learning and provide insight into corticostriatal circuits.

Details

Title: Subtitle: Temporal Learning Among Prefrontal and Striatal Ensembles
Creators: Eric Emmons - Department of Psychiatry, Yale University, New Haven, CT 06515, USA
Gabriela Tunes-Chiuffa - Universidade Federal do ABC, Sao Paulo 09210-580, Brazil
Jeeyu Choi - School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea
R Austin Bruce - Department of Neurology, University of Iowa, Iowa City, IA 52242, USA
Matthew A Weber - Department of Neurology, University of Iowa, Iowa City, IA 52242, USA
Youngcho Kim - Department of Neurology, University of Iowa, Iowa City, IA 52242, USA
Nandakumar S Narayanan - Department of Neurology, University of Iowa, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: Cerebral Cortex Communications, Vol.1(1), tgaa058
DOI: 10.1093/texcom/tgaa058
PMID: 34296121
PMCID: PMC8152894
NLM abbreviation: Cereb Cortex Commun
ISSN: 2632-7376
eISSN: 2632-7376
Grant note: DOI: 10.13039/100000025, name: National Institutes of Mental Health, award: R01; name: Titan Neurological Fund; name: Improvement of Higher Education Personnel
Language: English
Date published: 08/05/2020
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9984071995202771

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