Journal article
Temporal bone analysis of patients with presbycusis reveals high frequency of mitochondrial mutations
Hearing research, Vol.110(1), pp.147-154
1997
DOI: 10.1016/S0378-5955(97)00077-4
PMID: 9282897
Abstract
Presbycusis is a histologically and genetically heterogenous group of disorders, which lead to progressive, primarily sensorineural hearing loss with aging. Acquired mitochondrial DNA defects have been proposed as important determinants of aging, particularly in neuro-muscular tissues. The spiral ganglion and membranous labyrinth from archival temporal bones of 5 patients with presbycusis were examined for mutations within the mitochondrially-encoded cytochrome oxidase II gene. When compared to controls, results indicate that mitochondrial mutations in the peripheral auditory system occur commonly with age-related hearing loss, that there is great individual variability in both quantity and location of mutation accumulation, and that at least a proportion of presbycusis patients have a highly significant load of mutations in auditory tissue. This work supports the hypothesis that acquired mitochondrial mutations are a determinant of hearing loss in a subgroup of presbycusis patients.
Details
- Title: Subtitle
- Temporal bone analysis of patients with presbycusis reveals high frequency of mitochondrial mutations
- Creators
- Nathan Fischel-Ghodsian - Ahmanson Department of Pediatrics, Steven Spielberg Pediatric Research Center, Medical Genetics Birth Defects Center, Cedars-Sinai Research Institute and UCLA School of Medicine, 8700 Beverly Blvd., Los Angeles, CA 90048, USAYelena Bykhovskaya - Ahmanson Department of Pediatrics, Steven Spielberg Pediatric Research Center, Medical Genetics Birth Defects Center, Cedars-Sinai Research Institute and UCLA School of Medicine, 8700 Beverly Blvd., Los Angeles, CA 90048, USAKent Taylor - Ahmanson Department of Pediatrics, Steven Spielberg Pediatric Research Center, Medical Genetics Birth Defects Center, Cedars-Sinai Research Institute and UCLA School of Medicine, 8700 Beverly Blvd., Los Angeles, CA 90048, USATanaz Kahen - Ahmanson Department of Pediatrics, Steven Spielberg Pediatric Research Center, Medical Genetics Birth Defects Center, Cedars-Sinai Research Institute and UCLA School of Medicine, 8700 Beverly Blvd., Los Angeles, CA 90048, USARita Cantor - Ahmanson Department of Pediatrics, Steven Spielberg Pediatric Research Center, Medical Genetics Birth Defects Center, Cedars-Sinai Research Institute and UCLA School of Medicine, 8700 Beverly Blvd., Los Angeles, CA 90048, USAKaren Ehrenman - Ahmanson Department of Pediatrics, Steven Spielberg Pediatric Research Center, Medical Genetics Birth Defects Center, Cedars-Sinai Research Institute and UCLA School of Medicine, 8700 Beverly Blvd., Los Angeles, CA 90048, USARichard Smith - Molecular Otolaryngology Research Laboratories, Department of Otolaryngology – Head and Neck Surgery, The University of Iowa Hospitals and Clinics, Iowa City, IA, USAElizabeth Keithley - Division of Otolaryngology – Head and Neck Surgery, Department of Surgery, University of California, San Diego, La Jolla, CA, USA
- Resource Type
- Journal article
- Publication Details
- Hearing research, Vol.110(1), pp.147-154
- DOI
- 10.1016/S0378-5955(97)00077-4
- PMID
- 9282897
- NLM abbreviation
- Hear Res
- ISSN
- 0378-5955
- eISSN
- 1878-5891
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 1997
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984006325202771
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