Temporal bone carcinoma: Treatment patterns and survival

Kristen L Seligman; Daniel Q Sun; Patrick P Ten Eyck; Nathan M Schularick; Marlan R Hansen

doi:10.1002/lary.27877

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Temporal bone carcinoma: Treatment patterns and survival

Journal article

Peer reviewed

Temporal bone carcinoma: Treatment patterns and survival

Kristen L Seligman, Daniel Q Sun, Patrick P Ten Eyck, Nathan M Schularick and Marlan R Hansen

The Laryngoscope, Vol.130(1), pp.E11-E20

01/2020

DOI: 10.1002/lary.27877

PMCID: PMC6745298

PMID: 30874314

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Abstract

Carcinomas of the temporal bone are rare, and appropriate treatment, staging, and survival data are limited. This study evaluates clinical characteristics and survival rates for patients with temporal bone carcinoma treated with resection at a single tertiary-care institution, with a focus on the outcomes of patients with locally advanced disease including skull base and/or dural invasion. Retrospective chart review. Demographic, tumor-specific, and survival data were collected for patients with primary carcinomas of the external auditory canal with involvement of the temporal bone from 2003 to 2015. All patients were staged according to the modified Pittsburgh system. Kaplan-Meier and logistic regression analysis were used to calculate factor-specific survival outcomes. Sixty-seven patients met inclusion criteria; 85% were male. There were 43 squamous cell carcinomas (64%) and 24 basal cell carcinomas (BCCs) (36%). Tumor stage was 24 (36%) T2, 12 (18%) T3, and 31 (46%) T4 tumors; 53% had recurrent disease. Surgical management included 49 lateral temporal bone resections and 18 subtotal temporal bone resections. Kaplan-Meier analyses revealed more favorable 5-year survival rates associated with BCC histology (P = .01), lateral temporal bone resection compared to subtotal temporal bone resection (P < .01), lack of immunocompromise (P = .04), and absence of perineural/lymphovascular invasion (P = .01). Multivariate regression analysis did not yield statistically significant results. Factors predictive of more favorable survival include lack of immunocompromise, BCC histology, absence of perineural/lymphovascular invasion, and disease extent amenable to lateral temporal bone resection. Dural invasion is not an absolute contraindication to surgery, with a subset of patients surviving >5 years. 3 Laryngoscope, 130:E11-E20, 2020.

Aged

Bone Neoplasms - mortality

Bone Neoplasms - surgery

Carcinoma, Basal Cell - mortality

Carcinoma, Basal Cell - surgery

Carcinoma, Squamous Cell - mortality

Carcinoma, Squamous Cell - surgery

Female

Humans

Male

Neoplasm Invasiveness

Retrospective Studies

Risk Factors

Survival Rate

Temporal Bone - pathology

Details

Title: Subtitle: Temporal bone carcinoma: Treatment patterns and survival
Creators: Kristen L Seligman - University of Iowa
Daniel Q Sun - University of Iowa
Patrick P Ten Eyck - University of Iowa
Nathan M Schularick - Ear, Nose, and Throat SpecialtyCare of Minnesota, Minneapolis, Minnesota, U.S.A.
Marlan R Hansen - University of Iowa
Resource Type: Journal article
Publication Details: The Laryngoscope, Vol.130(1), pp.E11-E20
DOI: 10.1002/lary.27877
PMID: 30874314
PMCID: PMC6745298
NLM abbreviation: Laryngoscope
ISSN: 0023-852X
eISSN: 1531-4995
Grant note: T32 DC000040 / NIDCD NIH HHS UL1 TR002537 / NCATS NIH HHS
Language: English
Date published: 01/2020
Academic Unit: Molecular Physiology and Biophysics; Biostatistics; Neurosurgery; Otolaryngology
Record Identifier: 9984297615302771

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