Journal article
Temporal expression of immunoreactivity for heat shock protein 25 (Hsp25) in the rat periodontal ligament following transection of the inferior alveolar nerve
Brain research, Vol.979(1), pp.146-152
2003
DOI: 10.1016/S0006-8993(03)02889-0
PMID: 12850581
Abstract
The present study examined the immunohistochemical localization of heat shock protein 25 (Hsp25) during the regeneration of nerve fibers and Schwann cells in the periodontal ligament of the rat lower incisor following transection of the inferior alveolar nerve. In the untreated control group, the periodontal ligament of rat incisor did not contain any Hsp25-immunoreaction. On postoperative day 3 (PO 3d), a small number of Schwann cells with slender cytoplasmic processes exhibited Hsp25-immunoreactivity. From PO 5d to PO 21d, Hsp25-positive nerve fibers and Schwann cells drastically increased in number in the alveolar half of the ligament. Although the axons of some regenerating Ruffini-like endings also showed Hsp25-immunoreactions, the migrated Schwann cells were devoid of Hsp25-immunoreaction. Thereafter, Hsp25-positive structures decreased in number gradually to disappear from the periodontal ligament by PO 56d. This temporal expression of Hsp25 in the periodontal ligament well-reflected the regeneration process of the nerve fibers. Hsp25 in the regenerating nerve fibers and denervated Schwann cells most likely serves in modulating actin dynamics and as a cellular inhibitor of apoptosis, respectively.
Details
- Title: Subtitle
- Temporal expression of immunoreactivity for heat shock protein 25 (Hsp25) in the rat periodontal ligament following transection of the inferior alveolar nerve
- Creators
- Kenji Iijima - Division of Oral Anatomy, Department of Biological Science, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Niigata 951-8514, JapanFumiko Harada - Division of Oral Anatomy, Department of Biological Science, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Niigata 951-8514, JapanKooji Hanada - Division of Orthodontics, Department of Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, JapanKayoko Nozawa-Inoue - Division of Oral Anatomy, Department of Biological Science, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Niigata 951-8514, JapanMegumi Aita - Division of Oral Anatomy, Department of Biological Science, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Niigata 951-8514, JapanYukako Atsumi - Department of Oral Anatomy and Developmental Biology, Osaka University Graduate School of Dentistry, Suita, JapanSatoshi Wakisaka - Department of Oral Anatomy and Developmental Biology, Osaka University Graduate School of Dentistry, Suita, JapanTakeyasu Maeda - Division of Oral Anatomy, Department of Biological Science, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Niigata 951-8514, Japan
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.979(1), pp.146-152
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S0006-8993(03)02889-0
- PMID
- 12850581
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 2003
- Academic Unit
- Periodontics
- Record Identifier
- 9984065809802771
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