Journal article
Temporal lobe asymmetry in FDG-PET uptake predicts neuropsychological and seizure outcomes after temporal lobectomy
Epilepsy & behavior, Vol.78, pp.62-67
01/2018
DOI: 10.1016/j.yebeh.2017.10.006
PMCID: PMC6585418
PMID: 29175222
Abstract
The objective of this study was to determine whether preoperative [18F]fludeoxyglucose (FDG)-positron emission tomography (PET) asymmetry in temporal lobe metabolism predicts neuropsychological and seizure outcomes after temporal lobectomy (TL).
An archival sample of 47 adults with unilateral temporal lobe epilepsy who underwent TL of their language-dominant (29 left, 1 right) or nondominant (17 right) hemisphere were administered neuropsychological measures pre- and postoperatively. Post-TL seizure outcomes were measured at 1year. Regional FDG uptake values were defined by an automated technique, and a quantitative asymmetry index (AI) was calculated to represent the relative difference in the FDG uptake in the epileptic relative to the nonepileptic temporal lobe for four regions of interest: medial anterior temporal (MAT), lateral anterior temporal (LAT), medial posterior temporal (MPT), and lateral posterior temporal (LPT) cortices.
In language-dominant TL, naming outcomes were predicted by FDG uptake asymmetry in the MAT (r=−0.38) and LPT (r=−0.45) regions. For all patients, visual search and motor speed outcomes were predicted by FDG uptake asymmetry in all temporal regions (MPT, r=0.42; MAT, r=0.34; LPT, r=0.47; LAT, r=0.51). Seizure outcomes were predicted by FDG uptake asymmetry in the MAT (r=0.36) and MPT (r=0.30) regions. In all of these significant associations, greater hypometabolism in regions of the epileptic temporal lobe was associated with better postoperative outcomes.
Our results support the conclusion that FDG uptake asymmetry is a useful clinical tool in assessing risk for cognitive changes in patients being considered for TL.
•FDG uptake asymmetry in temporal lobe metabolism predicted visual search and motor speed outcomes following temporal lobectomy.•FDG uptake asymmetry in temporal lobe metabolism predicted naming outcomes following language-dominant temporal lobectomy.•FDG uptake asymmetry in the medial anterior temporal region predicted seizure outcomes at a 1-year follow-up.
Details
- Title: Subtitle
- Temporal lobe asymmetry in FDG-PET uptake predicts neuropsychological and seizure outcomes after temporal lobectomy
- Creators
- Janina Kamm - Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IA, USALaura L Boles Ponto - Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA, USAKen Manzel - Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IA, USAOwen J Gaasedelen - Department of Psychological and Quantitative Foundations, The University of Iowa, Iowa City, IA, USAYasunori Nagahama - Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USATaylor Abel - Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USADaniel Tranel - Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Epilepsy & behavior, Vol.78, pp.62-67
- DOI
- 10.1016/j.yebeh.2017.10.006
- PMID
- 29175222
- PMCID
- PMC6585418
- NLM abbreviation
- Epilepsy Behav
- ISSN
- 1525-5050
- eISSN
- 1525-5069
- Publisher
- Elsevier Inc
- Grant note
- name: Conte Center, award: 2P50MH094258-06; DOI: 10.13039/100000913, name: James S. McDonnell Foundation, award: 220020387; name: Spastic Paralysis Research Foundation
- Language
- English
- Date published
- 01/2018
- Academic Unit
- Neurology; Radiology; Psychological and Brain Sciences; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984051561702771
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