Journal article
Temporal lobe perceptual predictions for speech are instantiated in motor cortex and reconciled by inferior frontal cortex
Cell reports (Cambridge), Vol.42(5), pp.112422-112422
05/30/2023
DOI: 10.1016/j.celrep.2023.112422
PMID: 37099422
Abstract
Humans use predictions to improve speech perception, especially in noisy environments. Here we use 7-T functional MRI (fMRI) to decode brain representations of written phonological predictions and degraded speech signals in healthy humans and people with selective frontal neurodegeneration (non-fluent variant primary progressive aphasia [nfvPPA]). Multivariate analyses of item-specific patterns of neural activation indicate dissimilar representations of verified and violated predictions in left inferior frontal gyrus, suggestive of processing by distinct neural populations. In contrast, precentral gyrus represents a combination of phonological information and weighted prediction error. In the presence of intact temporal cortex, frontal neurodegeneration results in inflexible predictions. This manifests neurally as a failure to suppress incorrect predictions in anterior superior temporal gyrus and reduced stability of phonological representations in precentral gyrus. We propose a tripartite speech perception network in which inferior frontal gyrus supports prediction reconciliation in echoic memory, and precentral gyrus invokes a motor model to instantiate and refine perceptual predictions for speech.
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•Left precentral gyrus represents spoken-word phonology and weighted prediction error•Left inferior frontal gyrus represents verified and violated predictions independently•Frontal neurodegeneration impairs integration of speech predictions in anterior STG•A tripartite speech perception network using a predictive motor model is proposed
Cope et al. use multivariate 7-T fMRI in patients with language impairment from selective frontal neurodegeneration (nfvPPA) to show that precentral gyrus instantiates and refines perceptual speech predictions, while inferior frontal gyrus contains distinct representations of verified and violated predictions that support their reconciliation with sensory input in anterior STG.
Details
- Title: Subtitle
- Temporal lobe perceptual predictions for speech are instantiated in motor cortex and reconciled by inferior frontal cortex
- Creators
- Thomas E. Cope - Cambridge University Hospitals NHS Foundation TrustEdiz Sohoglu - Medical Research CouncilKatie A. Peterson - University of CambridgeP. Simon Jones - University of CambridgeCatarina Rua - University of CambridgeLuca Passamonti - University of CambridgeWilliam Sedley - Newcastle UniversityBrechtje Post - University of CambridgeJan Coebergh - Ashford and St Peter’s Hospital, Ashford TW15 3AA, UKChristopher R. Butler - Imperial College LondonPeter Garrard - St George's HospitalKhaled Abdel-Aziz - Ashford and St Peter’s Hospital, Ashford TW15 3AA, UKMasud Husain - University of OxfordTimothy D. Griffiths - Newcastle UniversityKaralyn Patterson - MRC Cognition and Brain Sciences UnitMatthew H. Davis - MRC Cognition and Brain Sciences UnitJames B. Rowe - MRC Cognition and Brain Sciences Unit
- Resource Type
- Journal article
- Publication Details
- Cell reports (Cambridge), Vol.42(5), pp.112422-112422
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.celrep.2023.112422
- PMID
- 37099422
- ISSN
- 2211-1247
- eISSN
- 2211-1247
- Language
- English
- Date published
- 05/30/2023
- Academic Unit
- Psychological and Brain Sciences
- Record Identifier
- 9984627296602771
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