Journal article
Temporal pattern and synergy influence activity of ERK signaling pathways during L-LTP induction
eLife, Vol.10, e64644
08/10/2021
DOI: 10.7554/eLife.64644
PMCID: 8363267
PMID: 34374340
Abstract
Long-lasting long-term potentiation (L-LTP) is a cellular mechanism of learning and memory storage. Studies have demonstrated a requirement for extracellular signal-regulated kinase (ERK) activation in L-LTP produced by a diversity of temporal stimulation patterns. Multiple signaling pathways converge to activate ERK, with different pathways being required for different stimulation patterns. To answer whether and how different temporal patterns select different signaling pathways for ERK activation, we developed a computational model of five signaling pathways (including two novel pathways) leading to ERK activation during L-LTP induction. We show that calcium and cAMP work synergistically to activate ERK and that stimuli given with large intertrial intervals activate more ERK than shorter intervals. Furthermore, these pathways contribute to different dynamics of ERK activation. These results suggest that signaling pathways with different temporal sensitivities facilitate ERK activation to diversity of temporal patterns.
Details
- Title: Subtitle
- Temporal pattern and synergy influence activity of ERK signaling pathways during L-LTP induction
- Creators
- Nadiatou T. Miningou Zobon - George Mason UniversityJoanna Jedrzejewska-Szmek - Polish Academy of SciencesKim T. Blackwell - George Mason University
- Resource Type
- Journal article
- Publication Details
- eLife, Vol.10, e64644
- DOI
- 10.7554/eLife.64644
- PMID
- 34374340
- PMCID
- 8363267
- NLM abbreviation
- Elife
- ISSN
- 2050-084X
- eISSN
- 2050-084X
- Publisher
- Elife Sciences Publications Ltd
- Number of pages
- 28
- Grant note
- 1515686 / joint NIH-NSF CRCNS program through NSF R01MH 117964 / NIMH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH)
- Language
- English
- Date published
- 08/10/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute
- Record Identifier
- 9984446398002771
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