Journal article
Temporal pole morphology and psychopathology in males with schizophrenia
Psychiatry research. Neuroimaging, Vol.132(2), pp.107-115
2004
DOI: 10.1016/j.pscychresns.2004.09.002
PMID: 15598545
Abstract
A dysfunction of the paralimbic system has been implicated in the pathophysiology of schizophrenia. The temporal pole (TP) is a relevant component of the paralimbic circuit. Functional and structural imaging studies have shown circumscribed abnormalities in the TP. Subjects were 30 controls and 30 schizophrenia patients. Cortical surface size and gray matter volume of the TP were accurately measured to explore the morphology of the TP cortex and the relationship of TP measures to clinical variables in patients with schizophrenia. Correlations between structural measures and clinical dimensions, duration of illness, and cumulative neuroleptic exposure were determined. Neither macroscopic abnormalities in the TP nor differences in the pattern of asymmetry were demonstrated. The TP volume was correlated negatively to the psychotic and disorganized dimension scores. No other significant correlations were found. No morphological abnormalities in the TP were found in patients with schizophrenia. Interestingly, a reduction in the TP volume, a higher-order multimodal association cortex, was associated with the severity of disorganized and psychotic symptoms.
Details
- Title: Subtitle
- Temporal pole morphology and psychopathology in males with schizophrenia
- Creators
- Benedicto Crespo-Facorro - Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USAPeggy C Nopoulos - Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USAEran Chemerinski - Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USAJae-Jin Kim - Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USANancy C Andreasen - Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USAVincent Magnotta - Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Psychiatry research. Neuroimaging, Vol.132(2), pp.107-115
- DOI
- 10.1016/j.pscychresns.2004.09.002
- PMID
- 15598545
- NLM abbreviation
- Psychiatry Res Neuroimaging
- ISSN
- 0925-4927
- eISSN
- 1872-7506
- Publisher
- Elsevier Ireland Ltd
- Language
- English
- Date published
- 2004
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984003998802771
Metrics
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