Journal article
Temporal stability of defibrillation thresholds with cardiac resynchronization therapy
Heart rhythm, Vol.8(7), pp.1008-1013
2011
DOI: 10.1016/j.hrthm.2011.02.006
PMID: 21315841
Abstract
Defibrillation thresholds (DFTs) are typically stable over time among patients with implantable cardioverter-defibrillators (ICDs). However, the impact of cardiac resynchronization therapy (CRT) on DFTs has not been studied systematically.
This study prospectively evaluated the effect of CRT and left ventricular (LV) chamber reverse remodeling on DFTs.
This prospective, multicenter study evaluated 54 cardiac resynchronization therapy defibrillator (CRT-D) patients. Echocardiography and DFTs were performed both at implantation and at 6 months after implantation. All patients received dual-coil leads and a CRT-D pulse generator. DFTs were measured using a binary search method and tuned biphasic waveforms, where the shock pulse widths were determined by the measured shock impedance. Echocardiograms were analyzed by an independent core laboratory with a responder defined as a decrease of left ventricular end systolic volume >15%.
The study cohort was 74% male, with a mean age of 68.7 ± 10.9 years. The baseline ejection fraction was 0.245 ± 0.076, and the mean New York Heart Association class was 2.9 ± 0.4. In CRT responders (n = 32) the mean DFT was 415.6 ± 108.1 V at implantation vs. 415.6 ± 124.7 V at 6 months (
P = .9), and in nonresponders (n = 19) the mean DFT was 452.6 ± 102 V at implantation vs. 447.4 ± 112.4 V at 6 months (
P = .8). There was no significant change in DFT peak voltage, delivered energy, or shock impedance over time.
DFTs were unchanged at 6 months in CRT patients with or without LV chamber reverse remodeling.
Details
- Title: Subtitle
- Temporal stability of defibrillation thresholds with cardiac resynchronization therapy
- Creators
- Michael R. Gold - Medical University of South CarolinaAmir Hedayati - St Vincent Medical CenterJamshid Alaeddini - Inland Cardiology, Spokane, WashingtonJohn P. Payne - University of Mississippi Medical CenterSteven Bailin - Iowa Heart Center, West Des Moines, IowaJ.J. Lacy Sturdivant - Medical University of South CarolinaSonar Pradhan - St. Jude Medical CenterAshish L. Oza - St. Jude Medical Center
- Resource Type
- Journal article
- Publication Details
- Heart rhythm, Vol.8(7), pp.1008-1013
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.hrthm.2011.02.006
- PMID
- 21315841
- ISSN
- 1547-5271
- eISSN
- 1556-3871
- Grant note
- St Jude Medical St. Jude Medical Medtronic Sorin Boston Scientific
- Language
- English
- Date published
- 2011
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984359861002771
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