Journal article
Temporally Evolving and Context-Dependent Functions of Cytokines That Regulate Murine Anti- Plasmodium Humoral Immunity
Pathogens (Basel), Vol.11(5), p.523
04/29/2022
DOI: 10.3390/pathogens11050523
PMCID: PMC9144513
PMID: 35631044
Abstract
Protective immunity against blood-stage
infection and the disease malaria depends on antibodies secreted from high-affinity B cells selected during the germinal center (GC) response. The induction and stability of the GC response require the activation and direct cell-cell communication between parasite-specific CD4 helper T cells and B cells. However, cytokines secreted by helper T cells, B cells, and multiple other innate and adaptive immune cells also contribute to regulating the magnitude and protective functions of GC-dependent humoral immune responses. Here, we briefly review emerging data supporting the finding that specific cytokines can exhibit temporally distinct and context-dependent influences on the induction and maintenance of antimalarial humoral immunity.
Details
- Title: Subtitle
- Temporally Evolving and Context-Dependent Functions of Cytokines That Regulate Murine Anti- Plasmodium Humoral Immunity
- Creators
- Fionna A Surette - University of IowaNoah S Butler - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Pathogens (Basel), Vol.11(5), p.523
- DOI
- 10.3390/pathogens11050523
- PMID
- 35631044
- PMCID
- PMC9144513
- NLM abbreviation
- Pathogens
- ISSN
- 2076-0817
- eISSN
- 2076-0817
- Grant note
- R01AI167058 / NIH HHS R01AI125446 / NIH HHS R01AI127481 / NIH HHS T32AI007485 / NIH HHS
- Language
- English
- Date published
- 04/29/2022
- Academic Unit
- Molecular Physiology and Biophysics; Microbiology and Immunology
- Record Identifier
- 9984297431602771
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