Temporally organized representations of reward and risk in the human brain

Vincent Man; Jeffrey Cockburn; Oliver Flouty; Phillip E Gander; Masahiro Sawada; Christopher K Kovach; Hiroto Kawasaki; Hiroyuki Oya; Matthew A Howard III; John P O'Doherty

doi:10.1038/s41467-024-46094-1

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Temporally organized representations of reward and risk in the human brain

Journal article

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Temporally organized representations of reward and risk in the human brain

Vincent Man, Jeffrey Cockburn, Oliver Flouty, Phillip E Gander, Masahiro Sawada, Christopher K Kovach, Hiroto Kawasaki, Hiroyuki Oya, Matthew A Howard III and John P O'Doherty

Nature communications, Vol.15(1), 2162

03/09/2024

DOI: 10.1038/s41467-024-46094-1

PMCID: PMC10924934

PMID: 38461343

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Abstract

The value and uncertainty associated with choice alternatives constitute critical features relevant for decisions. However, the manner in which reward and risk representations are temporally organized in the brain remains elusive. Here we leverage the spatiotemporal precision of intracranial electroencephalography, along with a simple card game designed to elicit the unfolding computation of a set of reward and risk variables, to uncover this temporal organization. Reward outcome representations across wide-spread regions follow a sequential order along the anteroposterior axis of the brain. In contrast, expected value can be decoded from multiple regions at the same time, and error signals in both reward and risk domains reflect a mixture of sequential and parallel encoding. We further highlight the role of the anterior insula in generalizing between reward prediction error and risk prediction error codes. Together our results emphasize the importance of neural dynamics for understanding value-based decisions under uncertainty.

Brain - diagnostic imaging

Humans

Reward

Details

Title: Subtitle: Temporally organized representations of reward and risk in the human brain
Creators: Vincent Man - California Institute of Technology
Jeffrey Cockburn - Division of the Humanities and Social Sciences, California Institute of Technology, Pasadena, CA, 91125, USA
Oliver Flouty - University of South Florida
Phillip E Gander - Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA
Masahiro Sawada - University of Iowa
Christopher K Kovach - University of Nebraska Medical Center
Hiroto Kawasaki - University of Iowa
Hiroyuki Oya - Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA
Matthew A Howard III - Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA
John P O'Doherty - California Institute of Technology
Resource Type: Journal article
Publication Details: Nature communications, Vol.15(1), 2162
DOI: 10.1038/s41467-024-46094-1
PMID: 38461343
PMCID: PMC10924934
NLM abbreviation: Nat Commun
eISSN: 2041-1723
Grant note: R01 MH111425 / NIMH NIH HHS
Language: English
Date published: 03/09/2024
Academic Unit: Neurology; Radiology; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology; Health, Sport, and Human Physiology
Record Identifier: 9984571354602771

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