Terahertz Spectroscopy of Tetrameric Peptides

Jens Neu; Elizabeth A Stone; Jacob A Spies; Golo Storch; Ayaka S Hatano; Brandon Q Mercado; Scott J Miller; Charles A Schmuttenmaer

doi:10.1021/acs.jpclett.9b01091

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Terahertz Spectroscopy of Tetrameric Peptides

Journal article

Peer reviewed

Terahertz Spectroscopy of Tetrameric Peptides

Jens Neu, Elizabeth A Stone, Jacob A Spies, Golo Storch, Ayaka S Hatano, Brandon Q Mercado, Scott J Miller and Charles A Schmuttenmaer

The journal of physical chemistry letters, Vol.10(10), pp.2624-2628

05/16/2019

DOI: 10.1021/acs.jpclett.9b01091

PMCID: PMC6936601

PMID: 31039310

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Abstract

Determining the sequence and structure of peptides is crucial for understanding their structure–property relationships. Among many techniques, structures are typically elucidated using nuclear magnetic resonance spectroscopy and single crystal X-ray diffraction measurements. In this study, we present terahertz time-domain spectroscopy (THz-TDS) as a complementary, nondestructive technique that is sensitive to both the primary and secondary structures of tetrapeptides. Using only a few milligrams of peptide, THz-TDS spectra have been measured, some of which have been supported by density functional theory (DFT) calculations, to distinguish six tetrameric peptides with similar primary and secondary structures.

Details

Title: Subtitle: Terahertz Spectroscopy of Tetrameric Peptides
Creators: Jens Neu - Department of Chemistry
Elizabeth A Stone - Department of Chemistry
Jacob A Spies - Energy Sciences Institute
Golo Storch - Department of Chemistry
Ayaka S Hatano - Department of Chemistry
Brandon Q Mercado - Department of Chemistry
Scott J Miller - Department of Chemistry
Charles A Schmuttenmaer - Energy Sciences Institute
Resource Type: Journal article
Publication Details: The journal of physical chemistry letters, Vol.10(10), pp.2624-2628
DOI: 10.1021/acs.jpclett.9b01091
PMID: 31039310
PMCID: PMC6936601
NLM abbreviation: J Phys Chem Lett
ISSN: 1948-7185
eISSN: 1948-7185
Publisher: American Chemical Society
Grant note: DOI: 10.13039/100000165, name: Division of Chemistry, award: 1465085; DOI: 10.13039/100006151, name: Basic Energy Sciences, award: DEFG02-07ER15909; DOI: 10.13039/501100001659, name: Deutsche Forschungsgemeinschaft, award: STO 1175/1-1; DOI: 10.13039/100000057, name: National Institute of General Medical Sciences, award: GM-096403, GM-068649; DOI: 10.13039/100000001, name: National Science Foundation, award: DGE-112249
Language: English
Date published: 05/16/2019
Academic Unit: Chemistry; Chemical and Biochemical Engineering
Record Identifier: 9984217438002771

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