Journal article
Test characteristics of faecal immunochemical tests (FIT) compared with optical colonoscopy
Journal of medical screening, Vol.21(3), pp.133-143
09/2014
DOI: 10.1177/0969141314541109
PMCID: PMC4143449
PMID: 24958730
Abstract
Faecal occult blood tests are often the initial test in population-based screening. We aimed to: 1) compare the results of single sample faecal immunochemical tests (FITs) with colonoscopy, and 2) calculate the sensitivity for proximal vs. distal adenomatous polyps or cancer.
Individuals scheduled for a colonoscopy were invited to complete a FIT prior to their colonoscopy preparation. FIT results were classified as positive, negative, or invalid. Colonoscopy reports were reviewed and abstracted. Because of product issues, four different FIT manufacturers were used. The test characteristics for each FIT manufacturer were calculated for advanced adenomatous polyps or cancer according to broad reason for colonoscopy (screening or surveillance/diagnostic).
Of those invited, 1,026 individuals (43.9%) completed their colonoscopy and had a valid FIT result. The overall sensitivity of the FITs (95% confidence intervals) was 0.18 (0.10 to 0.28) and specificity was 0.90 (0.87 to 0.91) for advanced adenomas or cancer. The sensitivity for distal lesions was 0.23 (0.11 to 0.38) and for proximal lesions was 0.09 (0.02 to 0.25). The odds ratio of an individual with a distal advanced adenoma or cancer testing positive was 2.68 (1.20 to 5.99). The two individuals with colorectal cancer tested negative, as did one individual with high-grade dysplasia.
The sensitivity of a single-sample FIT for advanced adenomas or cancer was low. Individuals with distal adenomas had a higher odds of testing positive than those with proximal lesions or no lesions.
Details
- Title: Subtitle
- Test characteristics of faecal immunochemical tests (FIT) compared with optical colonoscopy
- Creators
- Barcey T Levy - Department of Family Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242 Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242 barcey-levy@uiowa.eduCamden Bay - Department of Family Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242 Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242Yinghui Xu - Department of Family Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242Jeanette M Daly - Department of Family Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242George Bergus - Department of Family Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242Jeffrey Dunkelberg - Department of Internal Medicine, Division of Gastroenterology, Carver College of Medicine, Iowa City, IA 52242Carol Moss - Department of Family Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242
- Resource Type
- Journal article
- Publication Details
- Journal of medical screening, Vol.21(3), pp.133-143
- Publisher
- England
- DOI
- 10.1177/0969141314541109
- PMID
- 24958730
- PMCID
- PMC4143449
- ISSN
- 0969-1413
- eISSN
- 1475-5793
- Grant note
- RC1 CA144907 / NCI NIH HHS P30 CA086862 / NCI NIH HHS 1 RC1 CA144907-01 / NCI NIH HHS
- Language
- English
- Date published
- 09/2014
- Academic Unit
- Physician Assistant Studies; Psychiatry; Health Management and Policy; Epidemiology; Family and Community Medicine; Internal Medicine
- Record Identifier
- 9984024535902771
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