Test-retest reliability of tibiofemoral joint space width measurements made using a low-dose standing CT scanner

Neil A Segal; John Bergin; Andrew Kern; Christian Findlay; Donald D Anderson

doi:10.1007/s00256-016-2539-8

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Test-retest reliability of tibiofemoral joint space width measurements made using a low-dose standing CT scanner

Journal article

Peer reviewed

Test-retest reliability of tibiofemoral joint space width measurements made using a low-dose standing CT scanner

Neil A Segal, John Bergin, Andrew Kern, Christian Findlay and Donald D Anderson

Skeletal radiology, Vol.46(2), pp.217-222

02/2017

DOI: 10.1007/s00256-016-2539-8

PMCID: PMC5179299

PMID: 27909787

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Abstract

To determine the test-retest reliability of knee joint space width (JSW) measurements made using standing CT (SCT) imaging. This prospective two-visit study included 50 knees from 30 subjects (66% female; mean ± SD age 58.2 ± 11.3 years; BMI 29.1 ± 5.6 kg/m ; 38% KL grade 0-1). Tibiofemoral geometry was obtained from bilateral, approximately 20° fixed-flexed SCT images acquired at visits 2 weeks apart. For each compartment, the total joint area was defined as the area with a JSW <10 mm. The summary measurements of interest were the percentage of the total joint area with a JSW less than 0.5-mm thresholds between 2.0 and 5.0 mm in each tibiofemoral compartment. Test-retest reliability of the summary JSW measurements was assessed by intraclass correlation coefficients (ICC 2,1) for the percentage area engaged at each threshold of JSW and root-mean-square errors (RMSE) were calculated to assess reproducibility. The ICCs were excellent for each threshold assessed, ranging from 0.95 to 0.97 for the lateral and 0.90 to 0.97 for the medial compartment. RMSE ranged from 1.1 to 7.2% for the lateral and from 3.1 to 9.1% for the medial compartment, with better reproducibility at smaller JSW thresholds. The knee joint positioning protocol used demonstrated high day-to-day reliability for SCT 3D tibiofemoral JSW summary measurements repeated 2 weeks apart. Low-dose SCT provides a great deal of information about the joint while maintaining high reliability, making it a suitable alternative to plain radiographs for evaluating JSW in people with knee OA.

Reproducibility of Results

Prospective Studies

Humans

Middle Aged

Tibia - diagnostic imaging

Female

Male

Femur - diagnostic imaging

Imaging, Three-Dimensional

Osteoarthritis, Knee - diagnostic imaging

Radiographic Image Interpretation, Computer-Assisted

Tomography, X-Ray Computed - instrumentation

Details

Title: Subtitle: Test-retest reliability of tibiofemoral joint space width measurements made using a low-dose standing CT scanner
Creators: Neil A Segal - The University of Iowa, Iowa City, IA, USA. segal-research@kumc.edu
John Bergin - The University of Iowa, Iowa City, IA, USA
Andrew Kern - The University of Iowa, Iowa City, IA, USA
Christian Findlay - The University of Iowa, Iowa City, IA, USA
Donald D Anderson - Department of Orthopaedics and Rehabilitation, The University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Skeletal radiology, Vol.46(2), pp.217-222
DOI: 10.1007/s00256-016-2539-8
PMID: 27909787
PMCID: PMC5179299
NLM abbreviation: Skeletal Radiol
ISSN: 0364-2348
eISSN: 1432-2161
Publisher: Germany
Grant note: T35 HL007485 / NHLBI NIH HHS P50 AR055533 / NIAMS NIH HHS
Language: English
Date published: 02/2017
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Epidemiology; Orthopedics and Rehabilitation; Industrial and Systems Engineering
Record Identifier: 9984040015302771

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