Journal article
Testing for Dihydropyrimidine Dehydrogenase Deficiency to Individualize 5-Fluorouracil Therapy
Cancers, Vol.14(13), p.3207
06/30/2022
DOI: 10.3390/cancers14133207
PMCID: PMC9264755
PMID: 35804978
Abstract
Simple Summary 5-Fluorouracil (5-FU) is a chemotherapy drug that is commonly used to treat multiple cancers. Many people who are treated with 5-FU experience severe toxicity to the drug, and in severe cases, patients can die. This review discusses current methods for identifying people who are at high risk for severe side effects to 5-FU therapy. Severe adverse events (toxicity) related to the use of the commonly used chemotherapeutic drug 5-fluorouracil (5-FU) affect one in three patients and are the primary reason cited for premature discontinuation of therapy. Deficiency of the 5-FU catabolic enzyme dihydropyrimidine dehydrogenase (DPD, encoded by DPYD) has been recognized for the past 3 decades as a pharmacogenetic syndrome associated with high risk of 5-FU toxicity. An appreciable fraction of patients with DPD deficiency that receive 5-FU-based chemotherapy die as a result of toxicity. In this manuscript, we review recent progress in identifying actionable markers of DPD deficiency and the current status of integrating those markers into the clinical decision-making process. The limitations of currently available tests, as well as the regulatory status of pre-therapeutic DPYD testing, are also discussed.
Details
- Title: Subtitle
- Testing for Dihydropyrimidine Dehydrogenase Deficiency to Individualize 5-Fluorouracil Therapy
- Creators
- Robert B. Diasio - Mayo ClinicSteven M. Offer - Mayo Clinic
- Resource Type
- Journal article
- Publication Details
- Cancers, Vol.14(13), p.3207
- Publisher
- Mdpi
- DOI
- 10.3390/cancers14133207
- PMID
- 35804978
- PMCID
- PMC9264755
- ISSN
- 2072-6694
- eISSN
- 2072-6694
- Number of pages
- 13
- Grant note
- R01CA251065 / National Cancer Institute of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 06/30/2022
- Academic Unit
- Pathology
- Record Identifier
- 9984618507602771
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