Journal article
Th1-like Plasmodium-specific memory CD4+ T cells unexpectedly support humoral immunity
Cell reports (Cambridge), Vol.23(4), pp.1230-1237
04/24/2018
DOI: 10.1016/j.celrep.2018.04.048
PMCID: PMC7220064
PMID: 29694898
Abstract
Effector T-cells exhibiting features of either T helper 1 (Th1) or T follicular helper (Tfh) populations are essential to control experimental
Plasmodium
infection and are believed to be critical for resistance to clinical malaria. To determine whether
Plasmodium
-specific Th1- and Tfh-like effector cells generate memory populations that contribute to protection, we developed transgenic parasites that enable high-resolution study of anti-malarial memory CD4 T-cells in experimental models. We found that populations of both Th1- and Tfh-like
Plasmodium
-specific memory CD4 T-cells persist. Unexpectedly, Th1-like memory cells exhibit phenotypic and functional features of Tfh cells during recall and provide potent B-cell help and protection following transfer, characteristics that are enhanced following ligation of the T-cell co-stimulatory receptor OX40. Our findings delineate critical functional attributes of
Plasmodium
-specific memory CD4 T-cells and identify a host-specific factor that can be targeted to improve resolution of acute malaria and provide durable, long-term protection against
Plasmodium
parasite re-exposure.
Details
- Title: Subtitle
- Th1-like Plasmodium-specific memory CD4+ T cells unexpectedly support humoral immunity
- Creators
- Ryan A. Zander - University of IowaRahul Vijay - University of IowaAngela D. Pack - University of IowaJenna J. Guthmiller - University of IowaAmy C. Graham - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA Graduate Program in Biosciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA Center for Malaria Research, Penn State University, University Park, Pennsylvania 16802, USA Department of Biochemistry and Molecular Biology, Penn State University, University Park, Pennsylvania 16802, USA Center for Infectious Disease Research, Seattle, Washington 98109, USA Department of Global Health, University of Washington, Seattle, Washington 98109, USA Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa 52242, USA Current address: Blood Research Institute at the BloodCenter of Wisconsin, Milwaukee Wisconsin 53233, USA Current address: Department of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, USAScott E. Lindner - Biochemistry & Molecular BiologyAshley M. Vaughan - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA Graduate Program in Biosciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA Center for Malaria Research, Penn State University, University Park, Pennsylvania 16802, USA Department of Biochemistry and Molecular Biology, Penn State University, University Park, Pennsylvania 16802, USA Center for Infectious Disease Research, Seattle, Washington 98109, USA Department of Global Health, University of Washington, Seattle, Washington 98109, USA Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa 52242, USA Current address: Blood Research Institute at the BloodCenter of Wisconsin, Milwaukee Wisconsin 53233, USA Current address: Department of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, USAStefan H. I. Kappe - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA Graduate Program in Biosciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA Center for Malaria Research, Penn State University, University Park, Pennsylvania 16802, USA Department of Biochemistry and Molecular Biology, Penn State University, University Park, Pennsylvania 16802, USA Center for Infectious Disease Research, Seattle, Washington 98109, USA Department of Global Health, University of Washington, Seattle, Washington 98109, USA Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa 52242, USA Current address: Blood Research Institute at the BloodCenter of Wisconsin, Milwaukee Wisconsin 53233, USA Current address: Department of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, USANoah S. Butler - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA Graduate Program in Biosciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA Center for Malaria Research, Penn State University, University Park, Pennsylvania 16802, USA Department of Biochemistry and Molecular Biology, Penn State University, University Park, Pennsylvania 16802, USA Center for Infectious Disease Research, Seattle, Washington 98109, USA Department of Global Health, University of Washington, Seattle, Washington 98109, USA Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa 52242, USA Current address: Blood Research Institute at the BloodCenter of Wisconsin, Milwaukee Wisconsin 53233, USA Current address: Department of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, USA
- Resource Type
- Journal article
- Publication Details
- Cell reports (Cambridge), Vol.23(4), pp.1230-1237
- DOI
- 10.1016/j.celrep.2018.04.048
- PMID
- 29694898
- PMCID
- PMC7220064
- NLM abbreviation
- Cell Rep
- eISSN
- 2211-1247
- Language
- English
- Date published
- 04/24/2018
- Academic Unit
- Molecular Physiology and Biophysics; Microbiology and Immunology
- Record Identifier
- 9984297323902771
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