Journal article
Th17 cell cytokine secretion profile in host defense and autoimmunity
Inflammation research, Vol.61(2), pp.87-96
12/25/2011
DOI: 10.1007/s00011-011-0419-1
PMID: 22197935
Abstract
Objective and design
The goal of this review is to examine the effector functions of Th17 cells in host defense and autoimmunity.
Material
Published literature on Th17 cells was reviewed with a focus on the secreted products that mediate effector activities of these cells.
Results
Th17 cells secrete an array of cytokines that contribute to host defense and that bridge the innate and adaptive arms of the immune response. When this subset of T cells is dysregulated, autoimmune phenomena develop that contribute to the manifestations of many autoimmune diseases.
Conclusions
Th17 cells are positioned at a crossroads between innate and adaptive immunity and provide mediators that are essential for host defense. Current interest in harnessing this system for treatment of autoimmune disease will be challenged by the need to avoid abrogating these many protective functions.
Details
- Title: Subtitle
- Th17 cell cytokine secretion profile in host defense and autoimmunity
- Creators
- Kristen E. Graeber - Penn State Milton S. Hershey Medical CenterNancy J. Olsen - Penn State Milton S. Hershey Medical Center
- Resource Type
- Journal article
- Publication Details
- Inflammation research, Vol.61(2), pp.87-96
- Publisher
- SP Birkhäuser Verlag Basel
- DOI
- 10.1007/s00011-011-0419-1
- PMID
- 22197935
- ISSN
- 1023-3830
- eISSN
- 1420-908X
- Language
- English
- Date published
- 12/25/2011
- Academic Unit
- Dermatology; Stead Family Department of Pediatrics
- Record Identifier
- 9984296210302771
Metrics
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