Journal article
Thalamic Projections to the Posteromedial Cortex in the Macaque
Journal of comparative neurology (1911), Vol.507(5), pp.1709-1733
04/10/2008
DOI: 10.1002/cne.21647
PMCID: PMC3757573
PMID: 18253938
Abstract
The medial parietal, posterior cingulate and retrospenial cortices collectively constitute a region of cortex referred to as the posteromedial cortices (PMC). In an effort to shed light on the neuroanatomical organization of the PMC, we undertook a study to identify and analyze the thalamocortical connections of these cortices. Retrograde tracer injections were placed in the posterior cingulate (PCC), retrosplenial (RSC), medial parietal cortices (MPC) and posterior cingulate sulcus (PCS), and the labeling patterns within the thalamus were analyzed. Three afferent projection patterns were observed to the PMC from the thalamus: a PCC/RSC pattern that involved the anterior thalamic nuclei, a MPC pattern that involved the lateral posterior and pulvinar nuclei and a PCS pattern that involved the ventral thalamic nuclei. Additionally, a shared pattern of projections from the anterior intralaminar nuclei (AILN) and posterior thalamic nuclei (PTN) to all cortical regions of the PMC was observed. Our findings suggest that distinct regions within the PMC are supplied by distinctive patterns of thalamic input, but also share common projections from intralaminar and posterior thalamic sources. In addition, we relate our findings to functional abnormalities in aging and dementia, and address a domain-like pattern of thalamocortical labeling of the PMC that is drawn selectively and collectively from multiple thalamic nuclei.
Details
- Title: Subtitle
- Thalamic Projections to the Posteromedial Cortex in the Macaque
- Creators
- Joseph A Buckwalter - Division of Basic Biomedical Sciences, Laboratory of Neurological Sciences, University of South Dakota School of Medicine, Vermillion, South Dakota 57069, USAJosef Parvizi - Division of Basic Biomedical Sciences, Laboratory of Neurological Sciences, University of South Dakota School of Medicine, Vermillion, South Dakota 57069, USARobert J Morecraft - Division of Basic Biomedical Sciences, Laboratory of Neurological Sciences, University of South Dakota School of Medicine, Vermillion, South Dakota 57069, USAGary W Van Hoesen - Division of Basic Biomedical Sciences, Laboratory of Neurological Sciences, University of South Dakota School of Medicine, Vermillion, South Dakota 57069, USA
- Resource Type
- Journal article
- Publication Details
- Journal of comparative neurology (1911), Vol.507(5), pp.1709-1733
- DOI
- 10.1002/cne.21647
- PMID
- 18253938
- PMCID
- PMC3757573
- ISSN
- 0021-9967
- eISSN
- 1096-9861
- Grant note
- R01 NS046367 || NS / National Institute of Neurological Disorders and Stroke : NINDS
- Language
- English
- Date published
- 04/10/2008
- Academic Unit
- Orthopedics and Rehabilitation
- Record Identifier
- 9984002400202771
Metrics
19 Record Views