Journal article
Thalamic strokes that severely impair arousal extend into the brainstem
Annals of neurology, Vol.84(6), pp.926-930
12/2018
DOI: 10.1002/ana.25377
PMCID: PMC6344294
PMID: 30421457
Abstract
In this study, we evaluate the role of the thalamus in the neural circuitry of arousal. Level of consciousness within the first 12 hours of a thalamic stroke is assessed with lesion symptom mapping. Impaired arousal correlates with lesions in the paramedian posterior thalamus near the centromedian and parafascicular nuclei, posterior hypothalamus, and midbrain tegmentum. All patients with severely impaired arousal (coma, stupor) had lesion extension into the midbrain and/or pontine tegmentum, whereas purely thalamic lesions did not severely impair arousal. These results are consistent with growing evidence that pathways most critical for human arousal lie outside the thalamus. Ann Neurol 2018;84:926-930.
Details
- Title: Subtitle
- Thalamic strokes that severely impair arousal extend into the brainstem
- Creators
- Joseph Hindman - University of Iowa Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IAMark D Bowren - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IAJoel Bruss - Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IABrad Wright - Department of Radiology, University of Utah Health, Iowa City, IAJoel C Geerling - Iowa Neuroscience Institute, University of Iowa, Iowa City, IAAaron D Boes - Iowa Neuroscience Institute, University of Iowa, Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- Annals of neurology, Vol.84(6), pp.926-930
- DOI
- 10.1002/ana.25377
- PMID
- 30421457
- PMCID
- PMC6344294
- NLM abbreviation
- Ann Neurol
- ISSN
- 0364-5134
- eISSN
- 1531-8249
- Publisher
- United States
- Grant note
- K08 NS099425 / NINDS NIH HHS T35 HL007485 / NHLBI NIH HHS K12 NS098482 / NINDS NIH HHS K12 HD027748 / NICHD NIH HHS
- Language
- English
- Date published
- 12/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics); Neurosurgery
- Record Identifier
- 9984020762402771
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