Journal article
Thalidomide for the Treatment of Oral Aphthous Ulcers in Patients with Human Immunodeficiency Virus Infection
The New England journal of medicine, Vol.336(21), pp.1487-1493
05/22/1997
DOI: 10.1056/NEJM199705223362103
PMID: 9154767
Abstract
Aphthous ulceration of the mouth, though painful and annoying, is usually a self-limited problem in immunocompetent persons.
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In patients with human immunodeficiency virus (HIV) infection, however, aphthous ulcers frequently become progressive, destructive, and debilitating.
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Extremely painful, enlarging necrotic lesions can develop, resembling the large aphthous ulcers often seen in patients with Behçet's syndrome. The hypopharynx and esophagus may be involved. Aphthous ulcers can interfere with eating and lead to malnutrition and wasting. Even when the ulcers regress, they tend to recur.
Available treatments for aphthous ulcers in HIV-infected patients are unsatisfactory. Some success has been reported with topical, intralesional, . . .
Details
- Title: Subtitle
- Thalidomide for the Treatment of Oral Aphthous Ulcers in Patients with Human Immunodeficiency Virus Infection
- Creators
- Jeffrey M JacobsonJohn S GreenspanJohn SpritzlerNzeera KetterJohn L FaheyJ. Brooks JacksonLawrence FoxMiriam ChernoffAlbert W WuLaurie A MacPhailGuillermo J VasquezDavid A Wohl
- Resource Type
- Journal article
- Publication Details
- The New England journal of medicine, Vol.336(21), pp.1487-1493
- DOI
- 10.1056/NEJM199705223362103
- PMID
- 9154767
- NLM abbreviation
- N Engl J Med
- ISSN
- 0028-4793
- eISSN
- 1533-4406
- Publisher
- Massachusetts Medical Society
- Language
- English
- Date published
- 05/22/1997
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984046813102771
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