Journal article
Thalidomide in Low Intermittent Doses Does Not Prevent Recurrence of Human Immunodeficiency Virus-Associated Aphthous Ulcers
The Journal of infectious diseases, Vol.183(2), pp.343-346
01/15/2001
DOI: 10.1086/317928
PMID: 11120935
Abstract
A multicenter, double-blind, randomized, placebo-controlled study was conducted to determine the safety and efficacy of thalidomide in reduced, intermittent doses for preventing recurrences of oral and esophageal aphthous ulcers in patients with human immunodeficiency virus (HIV) infection. Forty-nine HIV-infected patients whose ulcers previously had healed as a result of thalidomide therapy were randomly assigned to receive either 100 mg of oral thalidomide or placebo 3 times per week for 6 months. Ulcers recurred in 14 (61%) of 23 thalidomide-randomized patients, compared with 11 (42%) of 26 placebo-randomized patients, with no significant difference in the median time to recurrence of ulcers (P = .221). There were no changes in plasma levels of HIV RNA, tumor necrosis factor (TNF)-α, and soluble TNF receptor II at the time of ulcer recurrence. Adverse events among patients treated with thalidomide included neutropenia (5 patients), rash (5 patients), and peripheral sensory neuropathy (3 patients). Thalidomide in lower intermittent doses is ineffective at preventing recurrence of aphthous ulcers in HIV-infected persons.
Details
- Title: Subtitle
- Thalidomide in Low Intermittent Doses Does Not Prevent Recurrence of Human Immunodeficiency Virus-Associated Aphthous Ulcers
- Creators
- Jeffrey M Jacobson - Department of Medicine, Mount Sinai School of MedicineJohn S Greenspan - Department of Stomatology, University of CaliforniaJohn Spritzler - Statistical and Data Analysis Center, Harvard School of Public HealthLawrence Fox - Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of HealthJohn L Fahey - Department of Medicine, University of CaliforniaJ. Brooks Jackson - Department of Pathology, Johns Hopkins UniversityMiriam Chernoff - Statistical and Data Analysis Center, Harvard School of Public HealthDavid A Wohl - Department of Medicine, University of North CarolinaJoseph J Pulvirenti - Division of Infectious Diseases, Cook County Hospital and Rush Medical SchoolThomas M Hooton - Department of Medicine, University of Washington School of MedicineCecilia Shikuma - Department of Medicine, University of Hawaii School of Medicine
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.183(2), pp.343-346
- Publisher
- The University of Chicago Press
- DOI
- 10.1086/317928
- PMID
- 11120935
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Language
- English
- Date published
- 01/15/2001
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047796802771
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