Journal article
That which does not kill me makes me stronger: adapting to chronic ER stress
Trends in biochemical sciences (Amsterdam. Regular ed.), Vol.32(10), pp.469-476
10/2007
DOI: 10.1016/j.tibs.2007.09.003
PMID: 17920280
Abstract
Cells respond to the accumulation of unfolded proteins by activating signal transduction cascades that improve protein folding. One example of such a cascade is the unfolded protein response (UPR), which senses protein folding stress in the endoplasmic reticulum (ER) and leads to improvement in the protein folding and processing capacity of the organelle. A central paradox of the UPR, and indeed of all such stress pathways, is that the response is designed to facilitate both adaptation to stress and apoptosis, depending upon the nature and severity of the stressor. Understanding how the UPR can allow for adaptation, instead of apoptosis, is of tremendous physiological importance. Recent advances have improved our understanding of ER stress and the vertebrate UPR, which suggest possible mechanisms by which cells adapt to chronic stress.
Details
- Title: Subtitle
- That which does not kill me makes me stronger: adapting to chronic ER stress
- Creators
- D Thomas Rutkowski - Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109, USARandal J Kaufman
- Resource Type
- Journal article
- Publication Details
- Trends in biochemical sciences (Amsterdam. Regular ed.), Vol.32(10), pp.469-476
- DOI
- 10.1016/j.tibs.2007.09.003
- PMID
- 17920280
- ISSN
- 0968-0004
- eISSN
- 1362-4326
- Grant note
- R01 HL052173 / NHLBI NIH HHS P01 HL057345 / NHLBI NIH HHS R01 DK042934 / NIDDK NIH HHS
- Language
- English
- Date published
- 10/2007
- Academic Unit
- Anatomy and Cell Biology; Internal Medicine
- Record Identifier
- 9984094393702771
Metrics
21 Record Views